Supplemental Data
Files in this Data Supplement:
- Supplemental Figure S3 (.pdf, 47 KB) - Structural alignment of ROP5BI with four pseudokinases of known structure
- Supplemental Figure Legends (.pdf, 39 KB)
- Supplemental Figure S1 (.pdf, 54 KB) - Alignment of full-length ROP5 isoforms from type I and II strains
- Supplemental Figure S8 (.pdf, 125 KB) - ROP5 has a degenerate, but well-ordered activation segment
- Supplemental Figure S4 (.pdf, 229 KB) - Overlay of ATP-bound and -unbound ROP5 structures
- Supplemental Figure S2 (.jpg, 111 KB) - Characterization of ROP5 R389D/K263S mutant parasites.
- Supplemental Figure S5 (.jpg, 105 KB) - Organization of the ROP5BI pseudoactive site
- Supplemental Figure S7 (.jpg, 170 KB) - The ROP5 pseudokinase domain is in a degenerate active conformation
- Supplemental Figure S6 (.jpg, 91 KB) - Comparison of the casein kinase 2 and ROP5 active sites
- Supplemental Figure S9 (.jpg, 218 KB) - The ROP5 N-terminal extension spans the N- and C-terminal lobes of the pseudokinase domain
