Anion Activation Site of Insulin-degrading Enzyme

Supplemental Data

Files in this Data Supplement:

• Supplemental Figure S1 (.pdf, 1.5 MB) - IDE thermal factors.
• Supplemental Figure S3 (.pdf, 5.5 MB) - Structural relationship of the proposed IDE ATP/polyanion binding fold to palm domain containing enzymes, surface electrostatics, and alternative binding sites.
• Supplemental Figure S2 (.pdf, 95 KB) - Ability of gamma-methylene-ATP verus ATP to increase the IDE-dependent hydrolysis of Abz-GGFLRKHGQ-EDDnp.