Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes

Supplemental Data

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Table 1 - Uptake clearance of 2 muM estrone-3-sulfate and demographic information on 28 human hepatocyte donors

  Supplemental Table 2 - Literature data used for the comparison between observed and predicted hepatic clearance

  Supplemental Figure 1 - Formation of M1, M2, M4 and repaglinide glucuronide in human hepatocytes...

  Supplemental Figure 2 - Representative uptake kinetic profiles after 2 min incubation for seven OATP substrates...

  Supplemental Figure 3 - Predicted and observed rosuvastatin and repaglinide cell concentrations...

  Supplemental Figure 4 - Relationship between uptake of estrone-3-sulfate...