Identification of Determinants Required for Agonistic and Inverse Agonistic Ligand Properties at the ADP Receptor P2Y₁₂

Supplemental Data

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Figure 1- Sequence alignment of P2Y12 with CXCR4

  Supplemental Figure 2 - Per residue change in free energy with and without ATP derivatives bound

  Supplemental Figure 3 - Analysis of the functional impact of endogenous nucleotide released from CHO cells

  Supplemental Table 1 - Purine compound library screening at the human WT P2Y12