Mechanisms Limiting Distribution of the Threonine-Protein Kinase B-RaF^V600E Inhibitor Dabrafenib to the Brain: Implications for the Treatment of Melanoma Brain Metastases

Data Supplement

Files in this Data Supplement:

• Figure 1 - : Accumulation of different concentrations... of dabrafenib in MDCKII- wild type and Bcrp1 transfected cell lines.
• Figure 2 - Intracellular accumulation of 3H-mitoxantrone (MTX; Bcrp probe substrate) in Bcrp1-transfected cell lines ...
• Figure 3 - Equilibrium dialysis in plasma and brain homogenate...