Targeted Genome-Wide Methylation and Gene Expression Analyses Reveal Signaling Pathways Involved in Ovarian Dysfunction after Developmental EDC Exposure in Rats

Supplemental Data

Supplemental Tables S1 and S2 and Supplemental Figure S1.

Files in this Data Supplement:

  • Supplemental Figure S1 - Canonical pathways common to all treatments wherein significant hypermethylation was observed (threshold P < 0.05).
  • Supplemental Table S1 - Genes examined in TLDA analysis.
  • Supplemental Table S2 - Normalized gene expression of candidate genes that had significant decrease in expression in high-dose MXC treated ovaries at PND 60. The control group was used as the calibrator group (Data Assist Software, Applied Bio Systems) and the false discovery rate calculated (Benjamini-Hochberg method, P < 0.05). A secondary t-test (two-tailed, nonparametric) was performed and P values reported as shown above.