The Last Enzyme of the
De Novo
Purine Synthesis Pathway 5-aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) Plays a Central Role in Insulin Signaling and the Golgi/Endosomes Protein Network
Supplemental Data
Files in this Data Supplement:
Online Figure 1
- Fig. 1 : Proteins enrichment analysis
Online Figure 2
- Fig. 2 : IR immunoprecipitation and mass spectrometry
Online Figure 3
- Fig 3 Kinetics of IR, ATIC and PTPLAD1 accumulation in G/E fractions
Online Figure 4
- Fig. 4: ATIC knockdown increases AMPK phosphorylation in HEK293 cells
Online Table 1
- Table 1 Peptides and MRM Transitions used for relative quantification
Online Table 2
- MS raw data of Table 1
Online Table 3
- List of protein interactions (Fig. 1B)
Online Table 4
- List of T2D common variants (Fig1.B)