The Last Enzyme of the De Novo Purine Synthesis Pathway 5-aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) Plays a Central Role in Insulin Signaling and the Golgi/Endosomes Protein Network

Supplemental Data

Files in this Data Supplement:

• Online Figure 1 - Fig. 1 : Proteins enrichment analysis
• Online Figure 2 - Fig. 2 : IR immunoprecipitation and mass spectrometry
• Online Figure 3 - Fig 3 Kinetics of IR, ATIC and PTPLAD1 accumulation in G/E fractions
• Online Figure 4 - Fig. 4: ATIC knockdown increases AMPK phosphorylation in HEK293 cells
• Online Table 1 - Table 1 Peptides and MRM Transitions used for relative quantification
• Online Table 2 - MS raw data of Table 1
• Online Table 3 - List of protein interactions (Fig. 1B)
• Online Table 4 - List of T2D common variants (Fig1.B)