Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase

Files in this data supplement:

• Supporting Information: Figures S1-S5 and Literature Cited (PDF, 3 MB)
• Figure S1: Lysine residue positions in Kelch KREP domain. (PDF, 640 KB)
• Figure S2: Overexpression of Kelch^FE results in a dominant-negative kelch-like phenotype. (PDF, 317 KB)
• Figure S3: Multiple RNAi lines are effective at inhibiting the proteasome as evidenced by Ub^G76V-GFP accumulation. (PDF, 1 MB)
• Figure S4: Proteasome inhibition by RNAi leads to high penetrance of kelch-like ring canals. (PDF, 873 KB)
• Figure S5: Loss of one copy of kelch dominantly enhances the kelch-like phenotype with proteasome inhibition. (PDF, 822 KB)