Table S1. Oligonucleotides used for cloning toxin domains of C. difficile VPI 10463. Table S2. Strains and plasmids used in this study. Table S3. Progression of infection in hamsters. Fig. S1. Analysis of serum antibody responses in llamas immunized with C. difficile toxin B. Fig. S2. Plasmid constructs for expression of VHH fragments in L. paracasei BL23. Fig. S3. Mapping of domain specificity of L. paracasei BL23 produced anti-toxin B VHH on toxin A and toxin B. Fig. S4. Epitope competition of toxin B neutralizing VHH fragments detected by ELISA. Fig. S5. Proteolytic stability of toxin B neutralizing VHH fragments against intestinal proteases.
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