From the Cover: Structural flexibility in the Burkholderia mallei genome -- Nierman et al. 101 (39): 14246 Data Supplement - HTML Page - index.htslp -- Proceedings of the National Academy of Sciences

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Nieman et al. 10.1073/pnas.0403306101.

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Supporting Figure 3

Fig. 3. MUMmer comparison analysis of the chromosomes in B. mallei and B. pseudomallei. Nucleotide sequence alignments were generated by using the software nucmer in the MUMmer package 3.0 (www.tigr.org/software ). The dot plots represent nucmer alignments between B. mallei (Bm) chromosome 1 and B. pseudomallei (Bp) chromosome 2 (A), chromosome 2 of Bm and Bp (B), Bm chromosome 1 and Bp chromosome 2 (C), and Bm chromosome 2 and Bp chromosome 1 (D). The forward matches are displayed in red, and the reverse matches are displayed in green.

Supporting Figure 4

Fig. 4. Deletion mutations of sucrose-resistant strains mapped with comparative genome hybridization analysis. Deleted regions in the B. mallei ATCC 23344 survivors (i.e., SR1-10) isolated from sucrose-containing plates are shown with divergent arrows connecting flanking IS elements that mediated deletion mutations around sacB, which is shown in red cross. Two genes present in IS elements are shown in thicker arrows, which also indicate their orientation.

Supporting Figure 5

Fig. 5. Relative metabolic capabilities. Pathway predictions specific to the metabolic capabilities of B. pseudomallei relative to B. mallei are highlighted in green. Analysis was based on a combination of bioinformatic gene function prediction comparisons and experimental substrate utilization patterns as assayed by Biolog Phenotype Microarray technology (1).

1. Bochner, B. R. (2003) Nat. Rev. Genet. 4, 309-314.

Supporting Figure 6

Fig. 6. SSR unit-number variation in isolates of B. mallei and B. pseudomallei. Up to 39 isolates of B. mallei and B. pseudomallei are compared at four selected SSR loci in ORF06228 (A), ORF00995 (B), ORF00780 (C), and ORF07512 (D). Repeat units in SSR loci are shown in alternating red and blue. Protein-coding three-base codons are denoted by spaces around them. Hyphens are used where repeat units in strains are absent compared to the longest allele in the list.