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Nakao et al. 10.1073/pnas.0405709101. |
Fig. 7. Responses during low-frequency burst stimulation (LFBS) trains. Traces show field responses to the first, 20th, and 600th bursts in LFBS of various conditions of LFBS applied to the medial perforant path (MPP) and basolateral amygdala (BLA) .
Fig. 8. Three-dimensional representations of the interplay of MPP–dentata gyrus (DG) and BLA–DG synaptic transmission. (A) First dimension of plastic modulations. The degree of MPP–DG synaptic activation determines the direction of homosynaptic modification, depicting a Bienenstock–Cooper–Monro (BCM)-like sinusoidal curve. (B) Second dimension of plastic modulations. The BCM-like curve is subject to BLA–DG heterosynaptic activity-dependent variation, making a pseudovertical shift as BLA activity increases. (C) Third dimension of plastic modulations. The capacity of the BLA to modulate MPP plasticity is itself modulated by synaptic efficacy of BLA–DG transmission, i.e., state-dependent neuromodulation of MPP plasticity.