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Table 3. Genes that were significantly (see Materials and Methods) down-regulated in the MIRKO (isolated loss of insulin receptor-mediated signaling) as compared to the Lox-control group are listed by functional class
|
GenBank accession no. |
Gene/protein |
Fold change in KO/Lox |
||
|
Metabolism-related |
||||
|
U79573 |
Apolipoprotein A-I |
0.26 |
||
|
AI853364 |
Fatty-acid desaturase 1 (Stearoyl CoA desaturase 1) |
0.73 |
||
|
AF058956 |
Sucinate-coenzyme A ligase, GDP-forming, b subunit |
0.84 |
||
|
Signaling-related |
||||
|
AI840738 |
Platelet-derived growth-factor receptor, a polypeptide |
0.43 |
||
|
AA034874 |
MAP/microtubule affinity-regulating kinase-like 1 (MARKL1) |
0.44 |
||
|
AF031939 |
Placental growth factor |
0.57 |
||
|
AI180687 |
Phosphodiesterase 4B, cAMP-specific |
0.61 |
||
|
AF031939 |
RalBP1-associated Eps domain-containing protein |
0.61 |
||
|
Y17345 |
Protein tyrosine phosphatase IF-1 (LMW) |
0.66 |
||
|
AI845103 |
Podocalyxin-like |
0.89 |
||
|
Transcription/translation-related |
||||
|
AI425994 |
Repilication intitiation origin |
0.59 |
||
|
AW125218 |
Histone Acetyltransferase Type B catalytic subunit |
0.59 |
||
|
U66249 |
Cut (Drosophila)-like 1 |
0.81 |
||
|
Transport/traffickin-related |
||||
|
U10120 |
N-ethylmaleimide sensitive fusion protein |
0.49 |
||
|
AF014461 |
Exocyst component protein 70 kDa homolog (Saccharomyces cerevisiae) |
0.72 |
||
|
AI852124 |
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) |
0.81 |
||
|
AW122882 |
Vesicle-associated membrane protein 2 |
0.82 |
||
|
U31510 |
ADP-ribosyltransferase 1 |
0.82 |
||
|
Membrane protein-related |
||||
|
X69966 |
Cadherin 4 |
0.65 |
||
|
X75927 |
ATP-binding cassette 2 |
0.67 |
||
|
U35741 |
Thiosulfate sulfurtransferase, mitochondrial |
0.68 |
||
|
AJ133427 |
Olfactory receptor 37d |
0.73 |
||
|
AB013729 |
Semaphorin 6C |
0.74 |
||
|
L48687 |
Sodium channel, voltage-gated, type I, beta polypeptide |
0.76 |
||
|
Proteasome/protease-related |
||||
|
M75721 |
Serine protease inhibitor 1-1 |
0.35 |
||
|
M75718 |
Serine protease inhibitor 1-4 |
0.40 |
||
|
AV365271 |
Neural precursor cell expressed, developmentally down-regulated gene 4a (ubiquitin-protein ligase) |
0.53 |
||
|
AI574278 |
Insulin-degrading enzyme |
0.68 |
||
|
AW125420 |
Similar to Ubiquitin 2 |
0.68 |
||
|
AI853269 |
Proteasome (prosome, macropain) subunit, b type, 2 |
0.86 |
||
GenBank accession numbers and the gene names (or the ones most closely matching) are given. The fold change represents the expression in MIRKO as compared with the Lox-control group.