This PDF file includes:

• Supplementary Text
• Fig. S1. Synthesis of LENK-SQ-Diox.
• Fig. S2. Synthesis of LENK-SQ-Dig.
• Fig. S3. Synthesis of LENK-SQ-Am.
• Fig. S4. ¹H spectrum of LENK-SQ bioconjugates.
• Fig. S5. ¹³C spectrum of LENK-SQ bioconjugates.
• Fig. S6. Size and zeta potential of LENK-SQ NPs kept at +4°C.
• Fig. S7. Hydrolysis of LENK or LENK-SQ-Am NPs in the presence of serum.
• Fig. S8. In vitro colloidal stability of LENK-SQ-Am NPs in mouse serum.
• Fig. S9. Biodistribution of fluorescent LENK-SQ-Am NPs or control fluorescent dye solution in mice with or without inflamed paw.
• Fig. S10. Toxicity study of LENK-SQ-Am NPs upon systemic administration.

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