Skip to main content
. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Neuropsychopharmacology. 2014 Jun 11;39(13):2963–2973. doi: 10.1038/npp.2014.142

Figure 3.

Figure 3

Fear memory and extinction in sham and nVH lesioned animals. A, Mean (± SEM) fear behavior (% time freezing) during fear conditioning is not significantly different between sham and nVH lesioned rats. B, The two groups of rats also do not differ in contextual fear memory assessed by exposure to the conditioning context 24 h following fear conditioning. C, Auditory fear memory by the presentation of conditioned stimulus (tone) 48 h following fear conditioning also did not differ in the sham and nVH lesioned rats. D, nVH lesion leads to impaired extinction of fear memory as lesioned animals show increased fear behavior compared to sham animals during presentation of repeated tone trials. E, Lesioned animals show impaired recall of fear memory as assessed by tone presentation, a day after extinction learning trials. The extinction training and recall data are presented as pool of 2 tone trials. *Two-way ANOVA of extinction training and recall showing significant effect of lesion (p=0.04 and p=0.008 respectively).