. Author manuscript; available in PMC: 2016 May 23.

Published in final edited form as: Diabetes. 2016 Feb 9;65(5):1231–1244. doi: 10.2337/db15-0996

Table 2.

Associations between methylation at three CpG sites at HIF3A and BMI

	Childhood				Adolescence
	Basic model (N=970)^*		Adjusted model (N=918)^†		Basic model (N=845)^‡		Adjusted model (N=804)^†
	Percentage change in BMI (95% CI)^§	p-value	Percentage change in BMI (95% CI)^§	p-value	Percentage change in BMI (95% CI)^§	p-value	Percentage change in BMI (95% CI)^§	p-value
cg22891070	0.44 (−0.35, 1.23)	0.27	0.45 (−0.32, 0.12)	0.25	0.66 (−0.31, 1.63)	0.19	0.30 (−0.67, 1.28)	0.54
cg27146050	0.62 (−1.69, 2.93)	0.60	0.34 (−1.89, 2.56)	0.77	4.66 (1.04, 8.29)	0.01	3.49 (−0.12, 7.10)	0.06
cg16672562	0.31 (−0.32, 0.93)	0.34	0.32 (−0.29, 0.93)	0.30	0.40 (−0.41, 1.20)	0.34	0.24 (−0.56, 1.05)	0.55

Childhood analyses are adjusted for age, sex and batch.

^‡

Adolescent analyses are adjusted for age, sex, smoking and batch.

^†

Basic model additionally adjusted for smoking, alcohol, maternal education, social class, maternal smoking, maternal smoking, maternal alcohol, birthweight and gestational age.

^§

Coefficients have been converted into percentage change in BMI for every 0.1 unit increase in methylation β value.