. Author manuscript; available in PMC: 2016 May 23.

Published in final edited form as: Diabetes. 2016 Feb 9;65(5):1231–1244. doi: 10.2337/db15-0996

Table 4.

Mendelian randomization analysis for associations between adolescent BMI and methylation at cg27146050.

Instrumental variable (IV)	Exposure (E)	Outcome (O)	Observed association between IV and O (c)^*		Expected association between IV and O (a × b)	Difference between observed (c) and expected (a × b) estimates
			N	β (95% CI)	β (95% CI)	P-value
Adolescent cis-SNP score	Adolescent methylation at cg27146050	Adolescent log BMI	831	−0.0381 (−0.2937, 0.2176)	0.1027 (0.0315, 0.1739)	0.30
Adolescent standardised 97 SNP allele score	Adolescent log BMI	Adolescent methylation at cg27146050	849	0.0014 (−0.0009, 0.0037)	0.0008 (0.0002, 0.0013)	0.55

Analyses are adjusted for bisulphite conversion batch only