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. Author manuscript; available in PMC: 2019 Aug 11.
Published in final edited form as: Oncogene. 2019 Feb 11;38(22):4412–4424. doi: 10.1038/s41388-019-0712-y

Figure 3. ‘Pluripotent factors drive a core regulatory transcriptome in cancer’.

Figure 3

(A) Venn diagrams of genes demonstrating ≥2-fold up- and down-regulation following culture in APSCE in prostate cancer cells (LNCaP and CWR22Rv1). The overlapping up- and down-regulated genes in prostate cancer cells are noted.

(B) Table of pathways most significantly altered following culture of prostate cancer cells (LNCaP and CWR22Rv1) in APSCE.

(C) Heatmap demonstrating transcript expression of core regulatory signature in APSCE compared to culture in FM in prostate (LNCaP), bladder (RT112), renal (Caki-2), breast (MCF7), colon (HCT116) and lung (H661) cancer cells. Measurements made by real time PCR. Data represents at least three independent experiments and is Log2 transformed.