Cumulative change in demand for lung cancer therapy in the United States between 2015–2040 when implementing Low-Dose Computed Tomography screening for lung cancer in 2018. Expressed as cumulative percentage change compared to no screening. All policies assumed a constant 50% adherence to screening. USPSTF, United States Preventive Task Force recommendations, annually screening current and former smokers aged 55–80 with at least a 30 pack-years smoking history that quit fewer than 15 years ago; CMS, the Centers for Medicare & Medicaid Services recommendations, annually screening current and former smokers aged 55–77 with at least a 30 pack-years smoking history that quit fewer than 15 years ago; Ontario, the most cost-effective policy from a study for Cancer Care Ontario, annually screening current and former smokers aged 55–75 with at least a 40 pack-years smoking history that quit fewer than 10 years ago.