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. Author manuscript; available in PMC: 2015 Apr 20.

Published in final edited form as: Neurotherapeutics. 2009 Apr;6(2):372–380. doi: 10.1016/j.nurt.2009.01.001

Pharmacokinetic analysis of NAX 5055 in CF-1 mice. A) time-dependent changes of NAX 5055 (solid line) following a bolus intraperitoneal administration of 2 mg/kg dose. Dash line represents a time-response of NAX 5055 at the same dose in protecting mice from seizures in the 6 Hz (32 mA) seizure model. B) a linear correlation between plasma levels of NAX 5055 and percent of seizure protection at doses 0.1, 0.25, 0.5, 2 and 4 mg/kg. Plasma levels were determined at 1 h after the administration of NAX 5055.

Pharmacokinetic analysis of NAX 5055 in CF-1 mice. A) time-dependent changes of NAX 5055 (solid line) following a bolus intraperitoneal administration of 2 mg/kg dose. Dash line represents a time-response of NAX 5055 at the same dose in protecting mice from seizures in the 6 Hz (32 mA) seizure model. B) a linear correlation between plasma levels of NAX 5055 and percent of seizure protection at doses 0.1, 0.25, 0.5, 2 and 4 mg/kg. Plasma levels were determined at 1 h after the administration of NAX 5055.