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. Author manuscript; available in PMC: 2021 Oct 8.
Published in final edited form as: Nature. 2020 Nov 12;598(7879):144–150. doi: 10.1038/s41586-020-2907-3

Extended Data Fig. 4 |. Extraction and distribution of electrophysiological features.

Extended Data Fig. 4 |

Panels af show data from the same exemplary cell. a, Membrane potential responses to the consecutive step current injections. Hyperpolarizing currents were used to compute the input resistance (274.80 MOhm) and membrane time constant tau (21.95 ms). b, The first five traces showing spikes were used to compute ISI adaptation index (1.26), ISI average adaptation index (1.15), AP amplitude adaptation index (0.91) and AP amplitude average adaptation index (0.99). c, The first AP elicited in this neuron. It was used to compute AP threshold (−40.18 mV), AP amplitude (81.17 mV), AP width (0.80 ms), AHP (−12.60 mV), ADP (0 mV), UDR (1.62) and latency of the first spike (69.28 ms). d, Regression line gives the rheobase estimate (20.44 pA). e, The highest firing trace with 32 APs. This trace was used to estimate the ISI CV (0.27), ISI Fano factor (0.0014 ms), AP CV (0.17) and AP Fano factor (1.32 mV). f, The lowest hyperpolarization trace was used to compute the sag ratio (1.17), sag time (0.26 ms), sag area (31.16 mV⋅ms) and rebound (17.84 mV). g, Eight important electrophysiological features are shown for all cells across all t-types. For t-types with at least three cells, horizontal lines show median values. See Supplementary File 2 for all electrophysiological features.