Figure 1.

Decreases in frontostriatal functional connectivity are correlated with reductions in suicidality following TMS. Left: Location of striatal seeds. Seed corresponded to the “prefrontal” projecting subregion of striatum per Tziortzi et al. (45). Center: Frontopolar cortex clusters where changes in RSFC to striatum and suicidality are correlated (p-FDR < 0.001). Right: Though changes in suicide self-rating were analyzed as a continuous measure, violin plots depict distributions of RSFC change by group for illustrative purposes. White circles denote medians, whiskers illustrate interquartile rang.