Table 2.

Prediction of all-cause mortality after adding E-cadherin measurements to standard diagnostic tests of cancer cell detachment from colorectal primary tumors

	E-cadherin Variable Added to Standard Tests
		Dichotomous E-cadherin Cut Point
	Continuous	0.52	0.60	0.85
C-Index, % (95% CI)	66 (58, 72)	51 (41, 59)	54 (45, 62)	56 (48, 63)
Reclassification Metric
Number (%) moved to higher risk category	47 (25)	11 (6)	27 (14)	41 (22)
Number (%) moved to lower risk category	55 (29)	93 (49)	83 (44)	70 (37)
Total number (%) reclassified	102 (54)	104 (55)	110 (59)	111 (59)
Reclassification Calibration Statistic P-value	0.1	0.1	0.1	0.2
Event Net Reclassification Index, % (95% CI)	14 (−11, 30)	−22 (−38, −7)	−7 (−23, 10)	3 (−15, 21)
Non-Event Net Reclassification Index, % (95% CI)	13 (3, 35)	54 (44, 63)	41 (29, 52)	24 (12, 37)
Integrated Discrimination Improvement, % (95% CI)	3.4 (1.9, 5.6)	4.3 (2.2, 6.8)	3.4 (1.8, 5.3)	3.7 (1.7, 5.9)

E-cadherin measured on a continuous average intensity scale of 0–3, then modeled as either continuous or dichotomized at a given cut point. Each C-index value is for a Cox model of all-cause mortality based on standard diagnostic tests of cancer cell detachment (lymph node evaluation and radiologic imaging) plus the respective E-cadherin variable. Reclassification metrics compare a Cox model of standard diagnostic tests estimating all-cause mortality to a Cox model of standard diagnostic tests plus the respective E-cadherin variable.

Table modified with permission from Table 4 in Busch EL, Don PK, Chu H, et al. Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors. BMC Cancer. 2018;18: 82. Published under a CC BY 4.0 license.