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. Author manuscript; available in PMC: 2021 Oct 19.
Published in final edited form as: Nature. 2021 Oct 6;598(7879):200–204. doi: 10.1038/s41586-021-03910-8

Figure 2. Cell Types in the Developing Human Neocortex Across Cortical Areas.

Figure 2.

a) Single-cells from the neocortex represented in UMAP space. Cells in the left-most UMAP plot are color-coded by cell type/state annotation. Feature plots on the right depict the expression pattern of major cell population markers (SOX2 – radial glia, EOMES – IPC, MKI67 – dividing cells, HOPX – outer radial glia, PDGFRA – OPC/Oligodendrocyte, AQP4 – astrocytes, BCL11B – deep layer excitatory neurons, SATB2 – supererficial layer excitatory neurons, NEUROD6 – broad excitatory neurons, DLX6-AS1 – inhibitory neurons). b) Hierarchical clustering of 138 neocortical clusters based on the Pearson correlations of cluster marker expression profiles across all neocortical stages sampled. Branches are color-coded by the major cell type assigned to each cluster group. Histograms below show the fraction of cells from each area contributing to a cluster. Bottom bar chart shows the relative number of cells in each cluster (log2-transformed numbers,0 to 20).