Fig. 4. NS-EM and neutralization analysis of mAb targeting NTD.

A. Surface and cartoon (adapted from PDB: 7A94 (39)) representation of the Spike NTD. The residue positions of mutations and deletions in circulating VOCs are indicated in three views of NTD. Fig. S1 lists mutations represented in each variant. B. Footprints for three NTD-targeted antibodies with the NTD “supersite”(26) indicated as a dotted line. The NTD-directed antibodies shown here define the approximate boundaries of the neutralizing epitope landscape. Additional NS-EM data are in Table S3. C. Fold-change in potency of pseudovirus neutralization experiments for each antibody-variant pair.