Table 2.

Final multivariable models of Grade 3+ INH-related toxicity in the prior 3 months.

	Model 1 Baseline alcohol use by self-report/PEth combined* (N=298)		Model 2 Baseline alcohol use by self-report alone** (N=298)		Model 3 Time-updated alcohol use by self-report/PEth* (N=297)
	aOR (95% CI)	p-value	aOR (95% CI)	p-value	aOR (95% CI)	p-value
Alcohol use		0.32		0.14		0.04
None	1.00		1.00		1.00
Low	0.43 (0.13–1.44)		0.38 (0.13–1.10)		0.10 (0.01–0.76)
Medium	0.36 (0.10–1.29)		0.30 (0.09–1.08)		0.23 (0.06–0.93)
High/very high	0.56 (0.16–1.93)		0.50 (0.12–2.04)		0.73 (0.23–2.26)
Age	0.98 (0.93–1.03)	0.47	0.98 (0.93–1.03)	0.43	0.96 (0.91–1.01)	0.15
Sex		0.83		0.69		0.58
Female	1.00		1.00		1.00
Male	1.11 (0.41–3.05)		1.21 (0.47–3.16)		1.32 (0.49–3.57)
Health status		0.39		0.41		0.24
Good/Fair/Poor	1.00		1.00		1.00
Excellent/very good	0.70 (0.31–1.59)		0.70 (0.31–1.61)		0.60 (0.26–1.40)
Study visit		0.02		0.02		0.04
3 months	1.00		1.00		1.00
6 months	0.33 (0.13–0.86)		0.33 (0.13–0.86)		0.37 (0.15–0.94)
INH adherence, prior 3 months						0.08
< 90%	-		-		1.00
≥ 90%	-		-		2.79 (0.90–8.61)

^*Self-report/PEth combined categories assigns the higher of the self-report and PEth categories. Self-report as below. PEth categories: None: PEth<8 ng/mL; Low: PEth 8–<50 ng/mL; Medium: PEth 50–200 ng/mL, High: PEth≥200 ng/mL.

^**Self-report categories: None: AUDIT-C=0; Low: AUDIT-C 1–2 for women and 1–3 for men; Medium: AUDIT-C 3–5 for women and 4–5 for men; High/very high: AUDIT-C ≥6