Figure 1.

Schematic diagrams representing all possible parental crosses and offspring genotypes for a single-construct gene drive system. A: For the autosomal case, the allele of interest is denoted by “T” and the null allele by “t,” respectively. We assume that offspring viability is gender-independent. Indices 1-14 represent the 14 ways in which offspring of different parental crosses may be rendered unviable by the construct, and correspond to constants c₁,…,c₁₄ in Equations 1-3. B: For an X-linked construct, the allele of interest is denoted by “X^T” and the null allele by “X^t.” Indices 1-14 represent the 14 ways in which offspring of different parental crosses may be rendered unviable, and correspond to constants c₁,…,c₁₄ in Equations 8-12. C: For a Y-linked construct, the allele of interest is denoted by “Y^T” and the null allele by “Y^t.” Here, there are only two ways in which offspring of different parental crosses may be rendered unviable, which correspond to the constants c₁,c₂ in Equations S16-S18.