A hybrid approach for the simulation of a nearly neutrally buoyant nanoparticle thermal motion in an incompressible Newtonian fluid medium

Abstract

A hybrid scheme based on Markovian fluctuating hydrodynamics of the fluid and a non-Markovian Langevin dynamics with the Ornstein-Uhlenbeck noise perturbing the translational and rotational equations of motion of a nanoparticle is employed to study the thermal motion of a nearly neutrally buoyant nanoparticle in an incompressible Newtonian fluid medium. A direct numerical simulation adopting an arbitrary Lagrangian-Eulerian based finite element method is employed in simulating the thermal motion of the particle suspended in the fluid contained in a cylindrical vessel. The instantaneous flow around the particle and the particle motion are fully resolved. The numerical results show that (a) the calculated temperature of the nearly neutrally buoyant Brownian particle in a quiescent fluid satisfies the equipartition theorem; (b) the translational and rotational decay of the velocity autocorrelation functions result in algebraic tails, over long time; (c) the translational and rotational mean square displacements of the particle obeys Stokes-Einstein and Stokes-Einstein-Debye relations, respectively; and (d) the parallel and perpendicular diffusivities of the particle closer to the wall are consistent with the analytical results, where available. The study has important implications for designing nanocarriers for targeted drug delivery.

1 Introduction

The cheif motivation for the present study is the simulation of a nanoparticle thermal motion in a fluid flow that occurs in targeted drug delivery [1, 2] where the drug carrying nanocarriers are intravascularly introduced into the vasculature. Nanoparticles allow more precise and successful infiltration of drugs to target cells. In general, nanoparticle drug-delivery systems have been shown to enhance the solubility of compounds, and to reduce the impact of drugs on non-target tissue, thereby eliminating unwanted and dangerous side effects. In order to more broadly integrate this technology into medicine, a precise understanding of how to guide the nanoparticle to the target site is necessary. To achieve this goal, as a first step, it is necessary to determine the motion of a nanocarrier (due to thermal and hydrodynamic effects) in a fluid medium. The nanocarrier with a loaded cargo may be studied later.

A nanoparticle suspended in a fluid undergoes random motion due to the thermal fluctuations in the fluid. As a consequence, translational and rotational degrees of freedom become important. In determining the translational and rotational motions of the nanoparticle in an incompressible Newtonian medium, there exist two methods that couple the thermal fluctuations with the hydrodynamic interactions. These are the generalized Langevin method [3] and the fluctuating hydrodynamics method [4]. Either procedure would require numerical simulations for covering extensive parameter space. The fluctuating hydrodynamics method essentially consists of adding stochastic stresses (random stress) to the stress tensor in the momentum equation of the fluid [5]. The stochastic stress tensor depends on the temperature and the transport coefficients of the fluid medium [6, 7]. Numerical simulations of the fluctuating hydrodynamics approach have been carried out employing the finite volume method [7–10], Lattice-Boltzmann method [11–17], finite element method [4, 18, 19] and stochastic immersed boundary method [20]. In the Langevin dynamics method, the effect of thermal fluctuations are incorporated as random forces and torques in the particle equation of motion [3, 21–26]. The properties of these forces depend on the grand resistance tensor. The tensor in turn depends on the fluid properties, particle shape, and its instantaneous location such as its proximity to a wall or a boundary.

The fluctuating hydrodynamics approach in an incompressible fluid [4] captures the correct hydrodynamic correlations and conserves thermal equipartition only after adding the mass correction [6]. On the other hand, the generalized Langevin dynamics yields the correct thermal equipartition (without any mass correction), but modifies the nature of the hydrodynamics correlations (due to the coupling of the fluid equations with the thermostat degrees of freedom).

Recently, we have formulated a novel hybrid scheme combining Markovian fluctuating hydrodynamics of the fluid and the non-Markovian Langevin dynamics with the Ornstein-Uhlenbeck noise perturbing the translational and rotational equations of motion of the nanocarrier [27]. For this hybrid scheme, we have verified the conservation of thermal equipartition and the nature of hydrodynamic correlations with well-known analytical results [6]. This scheme effectively produces a thermostat that also simultaneously preserves the true hydrodynamic correlations [27]. With this procedure, we have also evaluated adhesive interactions between a receptor and a ligand bond (tethered by a spring force) very close to the cylindrical wall at a specified finite temperature [28].

In this paper, we demonstrate the thermal equilibrium and hydrodynamic correlations of a nearly neutrally buoyant nanoparticle using our recently developed hybrid scheme. A direct numerical simulation procedure adopting an arbitrary Lagrangian-Eulerian based finite element method is employed to simulate the Brownian motion of a nearly neutrally buoyant particle in an incompressible Newtonian fluid contained in a horizontal micron sized cylindrical vessel. The results for the attainment of thermal equilibrium between the particle and the surrounding medium, diffusivity for the particle in the medium, effect of the presence of the confining vessel wall on particle displacement and diffusivity are evaluated and discussed in detail.

2 Formulation of the problem

The Brownian motion of a nearly neutrally buoyant nanoparticle in an incompressible Newtonian stationary fluid medium contained in a horizontal circular vessel is considered. The fluid and particle equations are formulated in an inertial frame of reference with the origin coinciding with the center of the vessel (Figure 1). The raidus, R, and the length, L, of the vessel (tube) are very large compared to the particle size, a, the radius of the particle. Initially, the nanoparticle is introduced either at the vessel centerline or at suitably chosen locations away from the center line towards the bounding wall. Initially both the fluid and particle are at rest. No body force is considered either for the particle or for the fluid domain. At time t = 0, the nanoparticle is subjected to Brownian motion. The motion of the nanoparticle is determined by the hydrodynamic forces and torques acting on the particle and the wall interactions.

Fig. 1.

Schematic representation of a nanoparticle in a cylindrical vessel (tube) (not to scale). Radius of the tube: R = 5 μm; Length of the tube: L = 10 μm; Radius of the nanoparticle: a = 250 nm; Viscosity of the fluid: μ = 10⁻³kg/ms; Density of the fluid and the nanoparticle: ρ^(f) = 10³kg/m³, 990kg/m³ ≤ ρ^(p) ≤ 1010kg/m³.

2.1 Hybrid Scheme: Governing equations and boundary conditions

The motion of an incompressible Newtonian fluid satisfies the conservation of mass and momentum given by

$$\nabla ·\mathit{u}=0;{\rho }^{(f)}({\mathit{u}}_t+(\mathit{u}·\nabla )\mathit{u})=\nabla ·\mathbf{\sigma },$$ (1)

$$\mathbf{\sigma }=-p\mathit{J}+\mu \left[\nabla \mathit{u}+{(\nabla \mathit{u})}^T\right]+\mathit{S}$$ (2)

where u and ρ^(f) are the velocity and density of the fluid, respectively, σ is the stress tensor, p is the pressure, J is the identity tensor, and μ is the dynamic viscosity. The random stress tensor S is assumed to be a Gaussian with

$$\begin{array}{l}\langle S_{ij}(\mathit{x},t)\rangle =0\&\\ \langle S_{ik}(\mathit{x},t)S_{lm}({\mathit{x}}^{\prime },t^{\prime })\rangle =2k_{B}T\mu ({\delta }_{il}{\delta }_{km}+{\delta }_{im}{\delta }_{kl})\delta (\mathit{x}-{\mathit{x}}^{\prime })\delta (t-t^{\prime }),\end{array}$$ (3)

where 〈 〉 is the ensemble average, k_B is the Boltzmann constant, T is the absolute temperature, δ_{i j} is the Kronecker delta, and the Dirac delta function δ(x − x′) denotes that the components of the random stress tensor are spatially uncorrelated (Markovian). The right hand side of equation (3) denotes the mean and variance of the thermal fluctuations chosen to be consistent with the fluctuation-dissipation theorem [5, 6, 29, 30]. By including this stochastic stress tensor due to the thermal fluctuations in the governing equations, the macroscopic hydrodynamic theory is generalized to include the mesoscopic scales ranging from tens of nanometers to a few microns.

For a rigid particle suspended in an incompressible Newtonian fluid, the translational and rotational motions of the particle satisfies Newton’s second law and the Euler equation, respectively. In the hybrid formulation, the time correlated noise is added into the particle equations of motion [27, 28]:

$$\begin{array}{l}m\frac{d\mathit{U}}{dt}=-{\int }_{\partial {\mathrm{\sum }}_p}\mathbf{\sigma }·\widehat{\mathit{n}}ds+{\int }_{-\infty }^{t_{-}}\mathbf{\xi }(t^{\prime })e^{-\mid t-t^{\prime }\mid /{\tau }_1}{dt}^{\prime },\\ \end{array}$$ (4)

$$\frac{d(\mathit{I}\mathbf{\omega })}{dt}=-{\int }_{\partial {\mathrm{\sum }}_p}(\mathit{x}-\mathit{X})\times [\mathbf{\sigma }·\widehat{\mathit{n}}]ds+{\int }_{-\infty }^{t_{-}}\mathbf{\eta }(t^{\prime })e^{-\mid t-t^{\prime }\mid /{\tau }_2}{dt}^{\prime },$$ (5)

where m is the mass of the particle, I is its moment of inertia, U and ω are the translational and angular velocities of the particle, respectively, X is the position of the centroid of the particle, (x − X) is a vector from the center of the particle to a point on its surface, ∂Σ_p denotes the particle surface, n̂ is the unit normal vector on the surface of the particle pointing into the particle, and the random force ξ and torque η are given by

$$\mathbf{\xi }(t^{\prime })={\int }_{\partial {\mathrm{\sum }}_p}\mathit{S}({\mathit{x}}^{\prime },t^{\prime })·\widehat{\mathit{n}}ds,$$ (6)

$$\mathbf{\eta }(t^{\prime })={\int }_{\partial {\mathrm{\sum }}_p}({\mathit{x}}^{\prime }-\mathit{X})\times (\mathit{S}({\mathit{x}}^{\prime },t^{\prime })·\widehat{\mathit{n}})ds,$$ (7)

for the Ornstein-Uhlenbeck process. The time integral in equations (4) and (5) excludes the frictional force and torque at the time instant t since it has already been accounted for in the hydrodynamic force and torque terms, respectively. The characteristic memory time for translational, τ₁ = n₁ ·Δt, and rotational, τ₂ = n₂ ·Δt, motions of the nanoparticle add certain amounts of memory from the previous history of fluctuations to the system. Here, Δt is the time step for the numerical simulation, n₁ and n₂ correspond to the number of time steps required to adequately represent the memory effects. These are variable quantities and are determined on the basis of satisfying the equipartition theorem. The amount of memory required by translational and rotational motions of the nanoparticle in order to satisfy the equipartition theorem are different. Hence τ₁ = τ₂ is not a necessary condition for the temperature of the particle to attain the preset temperature of the fluid. Equations (6) and (7) are the random force and torque acting on the nanoparticle at time t′ (a previous time instant). Since the random stress S(x, t) is Gaussian, ξ(t′) and η(t′) are also Gaussian with variance equivalent to the strength of the white noise in the Langevin equation. In the limit of the characteristic memory times τ₁, τ₂ → 0 (i.e. in the absence of memory), equations (4) and (5) reduce to the Newton’s second law and the Euler equations, respectively, which correspond to the Markovian fluctuating hydrodynamics.

The initial and boundary conditions for the problem are

$$\mathit{U}(t=0)=0;\mathit{u}(t=0)=0\text{on}{\mathrm{\sum }}_0-\partial {\mathrm{\sum }}_i,$$ (8)

$$\mathit{u}={\mathit{u}}_p\text{on}\partial {\mathrm{\sum }}_i;\mathbf{\sigma }·\widehat{\mathit{n}}=0\text{on}\partial {\mathrm{\sum }}_o,$$ (9)

$$\mathit{u}=\mathit{U}+\mathbf{\omega }\times (\mathit{x}-\mathit{X})\text{on}\partial {\mathrm{\sum }}_p,$$ (10)

where u_p is the prescribed velocity, Σ₀ is the domain occupied by the fluid and ∂Σ_i and ∂Σ_o are the inlet and outlet boundaries, respectively. The stochastic governing equations (1) – (5) along with the initial and boundary conditions (8) –(10) are solved numerically. It is assumed that there is no body torque acting at any point in the fluid and the viscous stress tensor, σ, is symmetric.

A numerical simulation at a mesoscopic scale involving a particle in a fluid could be based on a discretization of the equations (1) – (10). However, the discrete forms have to satisfy the fluctuation-dissipation theorem [7–9, 29–32]. Español and Zúñiga [18] and Español et al. [19] have shown that a well behaved set of discrete equations obtained in terms of the finite element shape functions based on the Delaunay triangulation conserves mass, momentum and energy while ensuring thermodynamic consistency. In the present study, we obtain the discrete hydrodynamic equations using finite element shape functions based on the Delaunay-Voronoi tetrahedrizations. The computational domain is covered by a finite element mesh generated using Delaunay-Voronoi methods. The fluid domain is discretized by quadratic irregular tetrahedral elements. A typical element is shown in Figure 2. Figure 3 shows a triangular mesh discretizing the surface of the fluid domain (cylinder) and the surface of the nanoparticle. The discretization of the fluid domain changes at each time step of the simulation due to the motion of the nanoparticle. The procedure for numerical simulation of the random stresses associated with the unstructured tetrahedron mesh while conserving the volume is described in detail in Uma et al. [4]. The details of combined fluid-solid weak formulation, generating random stress tensor for the tetrahedral finite element mesh, spatial discretization, mesh movement techniques, and temporal discretization of time derivatives are discussed in [3,4]. These details will not be repeated here for brevity. Briefly, the fluid domain is approximated by quadratic tetrahedral finite-elements (10 nodes defined per tetrahedron with 10 basis functions that are second-order polynomials). The discrete solution for the fluid velocity is approximated in terms of piecewise quadratic functions, and is assumed to be continuous over the domain (P2 elements). The discrete solution for the pressure is taken to be piecewise linear and continuous (P1 element). This P1/P2 element for the pressure and velocity is consistent with the Ladyzhenskaya-Babuska-Brezzi (LBB) or inf-sup condition and yields convergent solutions [33, 34].

Fig. 2.

Representation of a 10-node tetrahedron.

Fig. 3.

Finite element surface mesh of a cylindrical tube with one spherical nanoparticle.

The time scales involved in this study are (i) τ_b = m/ζ^(t), the Brownian relaxation time over which velocity correlations decay in the Langevin equation, (ii) τ_d = a²ζ^(t)/k_BT, the Brownian diffusive time scale over which the nanoparticle diffuses over a distance equal to its own radius, and (iii) τ_ν= a²/ν, the hydrodynamic time scale for momentum to diffuse over a distance equal to the radius of the nanoparticle, where ζ^(t) = 6πμa is the Stokes dissipative friction force coefficient for a sphere, a is the radius of the nanoparticle, and ν is the kinematic viscosity of the fluid. The time scale Δt for the numerical simulation has been chosen to be smaller than all the relevant physical time scales described above. The simulations presented in this study have been carried out for long enough durations to allow for the temperature of the particle to equilibrate; i.e., if N is the number of simulated time steps then N ·Δt = t ≫ τ_ν.

3 Numerical Results and Discussion

A nearly neutrally buoyant solid spherical particle of radius a = 250 nm is placed at the center of a cylindrical tube (R = 5 μm) containing a quiescent Newtonian fluid. The temperature of the fluid is initially set to T = 310K. For a given nanoparticle of radius a, and tube radius R, a ‘realization’ consists of N time steps (approximately 10s wall clock time for each time step that is generally considered in this study). The number of time steps depends upon equilibration of particle temperature, or determination of VACFs and MSD. In order to ensure the uniqueness of the realizations, different initial seeds are chosen for a Gaussian random number generator. In this section, we numerically predict (i) the translational and rotational temperatures of the nanoparticle, where the temperature calculation is carried out until thermal equilibration is obtained for the particle; (ii) the translational and rotational velocity distributions of the nanoparticle motion; (iii) the translational and rotational VACFs; (iv) the translational and rotational MSD of the particle for both ballistic and diffusive regimes; (v) the effects of the presence of the bounding wall on particles of different radii initially placed at various locations are evaluated for several cases with and without bulk flow. We compare the various numerical predictions with known analytical results, where available.

3.1 Equipartition theorem

Figure 4 shows that translational and rotational temperatures of nearly neutrally buoyant Brownian particles, thermally equilibrated, in a quiescent fluid medium are independent of the density of the particle in relation to that of fluid. The non-dimensionalized characteristic memory times τ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088 [27]. The error bars have been plotted from standard deviations of the temperatures obtained with 15 different realizations.

Fig. 4.

Translational and rotational temperatures of a nearly neutrally buoyant nanoparticle in a stationary fluid medium as a function of the particle density normalized with fluid density. The non-dimensionalized characteristic memory times are τ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088.

3.2 Maxwell-Boltzmann distribution

Figure 5 shows the numerically simulated components of U (Figure 5(a), (c)) and ω (Figure 5(b), (d)) (represented by three different symbols) of the nearly neutrally buoyant nanoparticle (a = 250 nm) are compared with the analytical Maxwell-Boltzmann distribution (MBD) with a zero mean and variance of k_BT/m and k_BT/I, respectively. The non-dimensionalized characteristic memory times are τ₁/τ_ν = 0.12 and τ₂/τ_ν= 0.088 [27]. It is observed that each degree of freedom individually follows MBD within 5% error (see dotted line in Figure 5). This validates the numerical procedure employed in this study.

Fig. 5.

Equilibrium probability of the (a) & (c) translational and (b) & (d) rotational velocities of the nanoparticle in a stationary Newtonian fluid medium for ρ^(p)/ρ^(f) = 0.99 ((a) & (b)) and 1.01 ((c) & (d)). The non-dimensionalized characteristic memory times are τ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088 [27].

3.3 Hydrodynamic correlations

A nanoparticle experiencing Brownian motion in a fluid is influenced by the hydrodynamic interactions. The fluid around the particle is dragged in the direction of motion of the particle. On the other hand, the motion of the particle is resisted by viscous forces arising due to its motion relative to the surrounding fluid. The momentum of the fluid surrounding the particle at any instant is related to its recent history. The friction coefficient is time dependent and is no longer given by the constant (steady flow) Stokes value.

Hauge and Martin-Löf [6] have analytically shown that the decay of the translational and rotational VACFs at long time obeys a power-law:

$$\frac{\langle \mathit{U}(t)\mathit{U}(0)\rangle }{\langle \mathit{U}(0)\mathit{U}(0)\rangle }\simeq \left(\frac{m{\rho }^{(f)1/2}}{12{\pi }^{3/2}{\mu }^{3/2}}\right)t^{-3/2}={Bt}^{-3/2}$$ (11)

$$\frac{\langle \mathbf{\omega }(t)\mathbf{\omega }(0)\rangle }{\langle \mathbf{\omega }(0)\mathbf{\omega }(0)\rangle }\simeq \left(\frac{\mathit{I}{\rho }^{(f)3/2}}{32{\pi }^{3/2}{\mu }^{5/2}}\right)t^{-5/2}={Ct}^{-5/2},$$ (12)

As for the short time behavior, the VACF is expected to adhere to the Langevin (white-noise) limit [35]: for translation VACF~ exp(−ζ^(t)t/m), and for rotation VACF~ exp(−ζ^(r)t/I), where ζ^(r) = 8πμa³.

Figure 6 shows the VACF of the translational and rotational motions of the nearly neutrally buoyant nanoparticle (a = 250 nm) in a quiescent fluid medium in a circular vessel as obtained from our numerical simulations. For determining the VACF of the nanoparticle, 15 different realizations have been employed with total computation of 15 × 100, 000 = 1, 500, 000 time steps. For this calculation, characteristic memory times are τ ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088 [27]. For the parameters considered in this study, our numerical simulations predict that the translational and rotational VACFs follow an exponential decay at short times and an algebraic tail at long times. Furthermore, the algebraic decay of the translational and rotational VACFs have power-law behavior characterized by ~ t^−3/2 and ~ t^−5/2, respectively. The error bars have been plotted from standard deviations of the decay at particular time instants obtained with 15 different realizations. Hence, our computed numerical results for nearly neutrally buoyant nanoparticle based on the hybrid non-Markovian fluctuating hydrodynamics approach are in good agreement with the predictions for short and long times (equations 11 and 12), respectively.

Fig. 6.

(a) & (c) Translational (B = mρ^(f)1/2/12π^3/2μ^3/2) and (b) & (d) rotational (C = Iρ^(f)3/2/32π^3/2μ^5/2) VACFs of the Brownian particle (a = 250 nm) in a fluid medium through a circular vessel using hybrid scheme. The non-dimensionalized characteristic memory times are τ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088 [27].

3.4 Diffusion of the nanoparticle

Figure 7 shows the numerically obtained translational and rotational MSDs (measures of diffusion) of a nearly neutrally buoyant nanoparticle (a = 250 nm) in a quiescent fluid medium, initially placed at the center of the vessel (R = 5 μm), for both short and long times. It is observed that in the regime where the particle’s motion is dominated by its own inertia (ballistic), the translational and rotational motions of the particle follow (3k_BT/m)t² and (3k_BT/I)t², respectively. In the diffusive regime, t ≫ τ_b, the translational and rotational MSDs increase linearly in time to follow $6D_{\infty }^{(t)}t$ (Stokes-Einstein relation) and $6D_{\infty }^{(t)}t$ (Stokes-Einstein-Debye relation), respectively, where $D_{\infty }^{(t)}=k_{B}T/{\zeta }^{(t)}$, and $D_{\infty }^{(r)}=k_{B}T/{\zeta }^{(r)}({\zeta }^{(r)}=8\pi \mu a^3)$ are the translational and rotational self-diffusion coefficients. The results are obtained from 15 realizations, each realization computed up to 100,000 time steps. The non-dimensionalized characteristic memory times are τ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088 [27].

Fig. 7.

The MSD of a nearly neutrally buoyant Brownian particle (a = 250 nm) in a stationary fluid medium using hybrid scheme. The non-dimensionalized characteristic memory times are τ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088 [27].

3.5 Wall effects

Figure 8 shows the numerically obtained parallel (x direction) and perpendicular (y direction) diffusivities of nearly neutrally buoyant particles of different radii initially placed at various distances from the tube wall, in a quiescent medium. As mentioned earlier, in the diffusive regime, the translational MSD of the particle increases linearly with time. We have numerically evaluated the gradient of the linear profile, normalized by the translational self-diffusion coefficient, $D_{\infty }^{(t)}$, plotted as a function of a/h. It is observed that for a given particle of radius a, the diffusivity of the particle decreases closer to the wall (i.e., as h → 0, D_w/D_∞ decreases). Similarly, for a given location of the particle from the wall, h, the diffusivity of the particle decreases for the larger particle (i.e., as a increases). The non-dimensionalized characteristic memory times are τ₁/τ_ν= 0.12 and τ₂/τ_ν= 0.088 [27]. Our numerical results are in agreement with the predictions of Happel and Brenner [36].

Fig. 8.

The translational diffusion coefficient of nearly neutrally buoyant Brownian particles of different radii a initially placed at different locations h from the wall of the circular vessel in a quiescent medium. Solid and dashed lines correspond to the perturbation solutions given in Happel and Brenner [36].

4 Conclusions

A hybrid scheme based on Markovian fluctuating hydrodynamics of the fluid and a non-Markovian Langevin dynamics with the Ornstein-Uhlenbeck noise perturbing the translational and rotational equations of motion of a nearly neturally buoyant nanoparticle is employed to simulate the Brownian motion in an incompressible Newtonian fluid. The translational and rotational motions of the nearly neutrally buoyant nanoparticle in a quiescent fluid medium is considered. At thermal equilibrium, the numerical predictions are validated with analytical results, where available.

We have numerically predicted:

• (a)the translational and rotational temperatures of a nearly neutrally buoyant particle in a quiscent fluid medium. The temperature calculation is carried out till thermal equilibration is obtained between the particle and the fluid medium.
• (b)the translational and rotational velocity distributions of a nearly neutrally buoyant nanoparticle motion in a quiescent fluid medium.
• (c)the translational and rotational VACFs of a nearly neutrally buoyant particle in a quiescent fluid. Over long times, the decay of the VACF captures algebraic tails for the translational (t^−3/2) and the rotational (t^−5/2) motions of the nanoparticle.
• (e)the translational and rotational MSDs of a nearly neutrally buoyant particle in a quiescent fluid, both for ballistic and diffusive regimes. At short times, translational and rotational MSDs in a quiescent fluid are proportional to t², and in the diffusive regime (t ≫ τ_b), they agree with the Stokes-Einstein and Stokes-Einstein-Debye theories.
• (f)the effects of the presence of the bounding wall on a nearly neutrally buoyant particles of different radii initially placed at various locations are evaluated for several cases in a quiscent fluid medium. The translational diffusion coefficients for parallel and perpendicular directions have been displayed. Very good agreement with published results, where available is also displayed.