Table 2.

Expression of HCV entry factor candidates in human and mice.

Gene		Most abundant tissue expression		Liver expression		Sequence identity (%)	Reference
human	mouse	human	mouse	human	mouse
CD81	cd81	ubiquitous	ubiquitous	+	+	96.6	Pileri et al. 1998
OCLN	ocln	all tight junctions	all tight junctions	+	+	94.5	Ploss et al. 2009
CLDN1	cldn1	skin, liver	skin, liver	+	+	97.2	Evans et al. 2007
SCARB1	scarb1	liver, adrenal tissue, placenta	liver, adrenal tissue, ovary	+	+	88.6	Scarselliet al. 2002
LDLR	Idlr	liver, intestine	liver, intestine	+	+	86.7	Molina et al. 2007, Agnello et al. 1999
NPC1L1	npc1l1	small intestine, liver, stomach	small intestine	+	-	84.7	Sainz et al. 2012
EGFR	egfr	ubiquitous, except central nervous tissue	ubiquitous, except central nervous tissue	+	+	95.1	Lupberger et al. 2011
EphA2	epha2	epithelial endothelial cells	epithelial endothelial cells	+	+	95.8	Lupberger et al. 2011
PCDHB5	pcdhb5	connective tissue	connective tissue	-	-	82.0	Wong-Staal et al. 2008
TfR1	tfr1	immature erythroid cells, placenta, liver	immature erythroid cells, placenta, liver	+	+	87.0	Danyelle et al. 2008
CLDN6	cldn6	embryonic tissue, pituitary gland, ovary	embryonic tissue, pituitary gland, ovary	-	-	95.0	Zheng et al. 2007, Meertens et al. 2008
CLDN9	cldn9	pituitary gland, lung, intestine	pituitary gland, lung, intestine	-	-	99.1	Zheng et al. 2007, Meertens et al. 2008
CD209	cd209	dendritic cells	dendritic cells	-	-	52.3	Gardner et al. 2003
CD209L/DC-SIGNR	signr1 (signr2-4)	lymph node, liver, placenta	lymph node, spleen, pancreas	+	+	54.5	Gardner et al. 2003