TABLE 1.
SYNAPOMORPHIES DEFINING A CLADE OF LEIOMYOMA AND LEIOMYOSARCOMA SPECIMENS IN COMPARISON TO NORMAL SPECIMENS (GDS533)
| A. Overexpressed synapomorphic genes: | ||
| D00596 | TYMS thymidylate synthetase | OE[1, 2] |
| B. Underexpressed synapomorphic genes: | ||
| L19871 | ATF3 activating transcription factor 3 | UE[1, 2] |
| U62015 | CYR61 cysteine-rich, angiogenic inducer, 61 | UE[1, 2] |
| X68277 | DUSP1 dual specificity phosphatase 1 | UE[1, 2] |
| V01512 | FOS v-fos FBJ murine osteosarcoma viral oncogene homolog | UE[1], NS [2] |
| L49169 | FOSB FBJ murine osteosarcoma viral oncogene homolog B | NS[1], UE[2] |
| J04111 | JUN v-jun sarcoma virus 17 oncogene homolog (avian) | UE[1, 2] |
| Y00503 | KRT19 keratin 19 | UE[1], NS [2] |
| U24488 | TNXB tenascin XB | UE[1], UE,OE[2] |
| C. Dichotomously-expressed synapomorphic genes: | ||
| M31994 | ALDH1A1 aldehyde dehydrogenase 1 family, member A1 | UE[1], NS[2] |
| X05409 | ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) | NS[1, 2] |
| D25304 | ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | NS[1, 2] |
| K03430 | C1QB complement component 1, q subcomponent, B chain | NS[1], OE[2] |
| U60521 | CASP9 caspase 9, apoptosis-related cysteine peptidase | NS[1, 2] |
| M73720 | CPA3 carboxypeptidase A3 (mast cell) | NS[1, 2] |
| HG2663-HT2759_at | Cpg-Enriched DNA, Clone S19 (HG3995-HT4265) | NS[1, 2] |
| M14676 | FYN oncogene related to SRC, FGR, YES | NS[1, 2] |
| M34677 | F8A1 coagulation factor VIII-associated (intronic transcript) 1 | OE,UE[2] |
| U60061 | FEZ2 fasciculation and elongation protein zeta 2 (zygin II) | NS[1, 2] |
| U86529 | GSTZ1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) | NS[1, 2] |
| HG358-HT358_at | Homeotic Protein 7, Notch Group (HG358-HT358) | NS[2] |
| AB002365 | KIAA0367 BCH motif-containing molecule at the carboxyl terminal region 1 | NS[1], OE,UE[2] |
| U37283 | MFAP5 microfibrillar associated protein 5 | NS[1, 2] |
| HG406-HT406_at | MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 | NS[1, 2] |
| M55593 | MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | NS[1], OE,UE[2] |
| M76732 | MSX1 msh homeobox homolog 1 | NS[1, 2] |
| L48513 | PON2 paraoxonase 2 | NS[1, 2] |
| U77594 | RARRES2 retinoic acid receptor responder (tazarotene induced) 2 | NS[1, 2] |
| M11433 | RBP1 retinol binding protein 1 | NS[1, 2] |
| L03411 | RDBP RD RNA binding protein | NS[1], OE[2] |
| Z29083 | TPBG trophoblast glycoprotein | NS[1, 2] |
| S73591 | TXNIP thioredoxin interacting protein | NS[1, 2] |
Synapomorphies include: OE gene, 8 UE genes, and 23 DE genes. Last column reports the status of the synapomorphies as described by [1] Hoffman et al. (2004) and [2] Quade et al. (2004) in their significant genes’ lists. DE = dichotomously-expressed; NS = not significant; OE = overexpressed; UN = underexpressed.