TABLE 2.
SYNAPOMORPHIES OF LEIOMYOMA SPECIMENS IN COMPARISON TO NORMAL SPECIMENS (GDS533)
| A. Overexpressed synapomorphic genes: | ||
| D16469 | ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 | NS[1, 2] |
| U07139 | CACNB3 calcium channel, voltage-dependent, beta 3 subunit | NS[1], OE[2] |
| M11718 | COL5A2 collagen, type V, alpha 2 | NS[1, 2] |
| U18300 | DDB2 damage-specific DNA binding protein 2, 48 kDa | NS[1, 2] |
| D38550 | E2F3 E2F transcription factor 3 | NS[1, 2] |
| M34677 | F8A1 coagulation factor VIII-associated (intronic transcript) 1 | NS[1, 2] |
| D89289 | FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | NS[1, 2] |
| D86962 | GRB10 growth factor receptor-bound protein 10 | NS[1, 2] |
| M32053 | H19, imprinted maternally expressed untranslated mRNA | NS[1, 2] |
| U07664 | HLXB9 homeobox HB9 | OE[1, 2] |
| D87452 | IHPK1 inositol hexaphosphate kinase 1 | NS[1, 2] |
| U51336 | ITPK1 inositol 1,3,4-triphosphate 5/6 kinase | NS[1, 2] |
| ABA002365 | KIAA0367 | NS[1], OE[2] |
| D78611 | MEST mesoderm specific transcript homolog (mouse) | OE[1], NS[2] |
| U19718 | MFAP2 microfibrillar-associated protein 2 | NS[1, 2] |
| M55593 | MMP2 matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72kDa type IV collagenase) | OE[1, 2] |
| U79247 | PCDH11X protocadherin 11 X-linked | NS[1, 2] |
| L24559 | POLA2 polymerase (DNA directed), alpha 2 (70 kDa subunit) | NS[1, 2] |
| M65066 | PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta | NS[1, 2] |
| D14694 | PTDSS1 phosphatidylserine synthase 1 | NS[1, 2] |
| U24186 | RPA4 replication protein A4, 34 kDa | NS[1, 2] |
| U85658 | TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | NS[1, 2] |
| D82345 | TMSL8 thymosin-like 8 | NS[1, 2] |
| D85376 | TRHR thyrotropin-releasing hormone receptor | NS[1, 2] |
| D00596 | TYMS* thymidylate synthetase | OE[1, 2] |
| B. Underexpressed synapomorphic genes: | ||
| X0330 | ADH1B alcohol dehydrogenase IB (class I), beta polypeptide | NS[1, 2] |
| M31994 | ALDH1A1* aldehyde dehydrogenaes 1 family, member A1 | UE[1], NS[2] |
| X05409 | ALDH2* aldehyde dehydrogenase 2 family (mitochondrial) | NS[1, 2] |
| L19871 | ATF3* activating transcription factor 3 | UE[1, 2] |
| U60521 | CASP9 caspase 9, apoptosis-related cysteine peptidase | NS[1, 2] |
| D49372 | CCL11 chemokine (C—C motif) ligand 11 | NS[1, 2] |
| X05323 | CD200 molecule | NS[1, 2] |
| M83667 | CEBPD CCAAT/enhancer binding protein (C/EBP), delta | NS[1, 2] |
| U90716 | CXADR coxsackie virus and adenovirus receptor | NS[1, 2] |
| M21186 | CYBA cytochrome b-245, alpha polypeptide | NS[1, 2] |
| U62015 | CYR61* cysteine-rich, angiogenic inducer, 61 | UE[1, 2] |
| Z22865 | DPT dermatopontin | NS[1, 2] |
| X56807 | DSC2 desmocollin 2 | NS[1, 2] |
| X68277 | DUSP1* dual specificity phosphatase 1 | UE[1, 2] |
| V01512 | FOS* v-fos FBJ murine osteosarcoma viral oncogene homolog | UE[1], NS[2] |
| L49169 | FOSB FBJ murine osteosarcoma viral oncogene homolog B | NS[1], UE[2] |
| L11238 | GP5 glycoprotein V (platelet) | NS[1, 2] |
| M36284 | GYPC glycophorin C (Gerbich blood group) | NS[1, 2] |
| M60750 | HIST1H2BG histone cluster 1, H2bg | NS[1, 2] |
| X79200 | Homo spaiens mRNA for SYT-SSX protein | NS[1, 2] |
| X92814 | HRASLS3 HRAS-like suppressor 3 | NS[1, 2] |
| M62831 | IER2 immediate early response 2 | NS[1, 2] |
| J04111 | JUN* v-jun sarcoma virus 17 oncogene homolog (avian) | UE[1, 2] |
| Y00503 | KRT19* keratin 19 | NS[1, 2] |
| X89430 | MECP2 methyl CpG binding protein 2 (Rett syndrome) | NS[1, 2] |
| U46499 | MGST1 microsomal glutathione S-transferase 1 | NS[1, 2] |
| M93221 | MRC1 mannose receptor, C type 1 | NS[1, 2] |
| M76732 | MSX1* msh homeobox homolog 1 (Drosophila) | NS[1, 2] |
| S71824 | NCAM1 neural cell adhesion molecule 1 | OE[1], NS[2] |
| X70218 | PPP4C protein phosphatase 4 | NS[1, 2] |
| U02680 | PTK9 protein tyrosine kinase 9 | NS[1, 2] |
| U79291 | PTPN11 protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | NS[1, 2] |
| U77594 | RARRES2* retinoic acid receptor responder (tazarotene induced) 2 | NS[1, 2] |
| M11433, X07438 | RBP1* retinol binding protein 1, cellular | NS[1, 2] |
| L20859 | SLC20A1 solute carrier family 20 (phosphate transporter), member 1 | NS[1, 2] |
| M97935 | STAT1 signal transducer and activator of transcription 1, 91kDa | NS[1, 2] |
| J04152 | TACSTD2 tumor-associated calcium signal transducer 2 | NS[1, 2] |
| X14787 | THBS1 thrombospondin 1 | NS[1, 2] |
| U24488 | TNXB* tenascin XB | UE[1, 2] |
| Z29083 | TPBG* trophoblast glycoprotein | NS[1, 2] |
| X51521 | VIL2 villin 2 (ezrin) | UE[1], NS[2] |
| D87716 | WDR43 WD repeat domain 43 | NS[1, 2] |
| C. Dichotomously-expressed synapomorphic genes: | ||
| ABCB1; ADRM1; AIM1; ALDH1A3; AMDD; ARHGEF6; ARL4D; ATP5B; Atp8a2; C1QB; CA9; CALM2; CTSB; CCRL2; CD52; CD99; CPA3; DPYD; DSG2; Emx2; FEZ2; FLNA; FOXO1A; FYN; GAPDH; GNB3; GSTZ1; H1F0; H2-ALPHA; HBG2; Ubx, Notch1; Hox5.4; HTR2C; ICA1; IGF2; INSR; ITGA6; ITGA9; KCNK1; KIAA0152; MAP1D; MATK; MBP; MDM4; MFAP5; MFI2 antigen p97; MLH1; MPZ; NDUFS1; NELL2; NNAT; NOS3; NR4A1; OASL; ODC1; OLFM1; PKN2; PON2; PRMT2; PSMC3; PTR2; RANBP2; RBMX; RDBP; RHOG; SAFB2; SCRIB; SELFP; SERPINF1; SMS; SPOCK2; ST3GAL1; THRA; TNXB; TTLL4; TXNIP; UPK2; XA; ZNF43 | ||
These comprise: 25 OE genes, 42 UE genes, and 79 DE genes.
Asterisk (*) indicates a synapomorphy for leiomyosarcoma as well. Last column reports the status of the synapomorphies as described by [1] Hoffman et al. (2004) and [2] Quade et al. (2004) in their significant genes lists.