Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1976 Dec;39(12):1236–1239. doi: 10.1136/jnnp.39.12.1236

Large cerebral vessel disease in sickle cell anaemia.

L Boros, C Thomas, W J Weiner
PMCID: PMC492572  PMID: 1011036

Abstract

An 18 year old male with documented sickle cell disease was admitted to the hospital for the final time in coma. Cerebral angiography revealed multiple stenotic lesions of the large cerebral vessels. The pathology of this large vessel involvement is demonstrated and the potential contribution of large as opposed to small cerebral vessel disease in the neurological manifestations of sickle cell anaemia is discussed.

Full text

PDF
1236

Images in this article

1237Image
on p.1237
1237Image
on p.1237

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adeloye A., Ogbeide M. I., Odeku E. L. Massive intracranial hemorrhage in sickle cell anemia. Neurology. 1970 Dec;20(12):1165–1170. doi: 10.1212/wnl.20.12.1165. [DOI] [PubMed] [Google Scholar]
  2. Armaly M. F. Ocular manifestations in sickle cell disease. Arch Intern Med. 1974 Apr;133(4):670–679. [PubMed] [Google Scholar]
  3. BAIRD R. L., WEISS D. L., FERGUSON A. D., FRENCH J. H., SCOTT R. B. STUDIES IN SICKLE CELL ANEMIA. XXI. CLINICO-PATHOLOGICAL ASPECTS OF NEUROLOGICAL MANIFESTATIONS. Pediatrics. 1964 Jul;34:92–100. [PubMed] [Google Scholar]
  4. Bridgers W. H. Cerebral vascular disease accompanying sickle cell anemia. Am J Pathol. 1939 May;15(3):353–362.5. [PMC free article] [PubMed] [Google Scholar]
  5. Cheatham M. L., Brackett C. E. Problems in management of subarachnoid hemorrhage in sickle cell anemia. J Neurosurg. 1965 Nov;23(5):488–493. doi: 10.3171/jns.1965.23.5.0488. [DOI] [PubMed] [Google Scholar]
  6. DIGGS L. W., VORDER BRUEGGE C. F. Vascular occlusive mechanisms in sickle cell disease. J Natl Med Assoc. 1954 Jan;46(1):46–49. [PMC free article] [PubMed] [Google Scholar]
  7. GREER M., SCHOTLAND D. Abnormal hemoglobin as a cause of neurologic disease. Neurology. 1962 Feb;12:114–123. doi: 10.1212/wnl.12.2.114. [DOI] [PubMed] [Google Scholar]
  8. Konotey-Ahulu F. I. The sickle cell diseases. Clinical manifestations including the "sickle crisis". Arch Intern Med. 1974 Apr;133(4):611–619. [PubMed] [Google Scholar]
  9. Portnoy B. A., Herion J. C. Neurological manifestations in sickle-cell disease, with a review of the literature and emphasis on the prevalence of hemiplegia. Ann Intern Med. 1972 Apr;76(4):643–652. doi: 10.7326/0003-4819-76-4-643. [DOI] [PubMed] [Google Scholar]
  10. Seeler R. A. Deaths in children with sickle cell anemia. A clinical analysis of 19 fatal instances in Chicago. Clin Pediatr (Phila) 1972 Nov;11(11):634–637. doi: 10.1177/000992287201101111. [DOI] [PubMed] [Google Scholar]
  11. Solomon G. E., Hilal S. K., Gold A. P., Carter S. Natural history of acute hemiplegia of childhood. Brain. 1970;93(1):107–120. doi: 10.1093/brain/93.1.107. [DOI] [PubMed] [Google Scholar]
  12. Stockman J. A., Nigro M. A., Mishkin M. M., Oski F. A. Occlusion of large cerebral vessels in sickle-cell anemia. N Engl J Med. 1972 Oct 26;287(17):846–849. doi: 10.1056/NEJM197210262871703. [DOI] [PubMed] [Google Scholar]
  13. Suzuki J., Takaku A. Cerebrovascular "moyamoya" disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol. 1969 Mar;20(3):288–299. doi: 10.1001/archneur.1969.00480090076012. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES