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. 1975 Apr 5;112(7):852–853.

Extensive intraglomerular fibrin deposition after renal transplantation: recovery without anticoagulation.

B S Kaplan, P G Chassot, J Knaack, D Morehouse, J G Beaudoin, R D Guttmann
PMCID: PMC1958959  PMID: 1091344

Abstract

Acute renal failure developed in a 55-year-old man 6 days after he had received a cadaver renal allograft. This was associated with thrombocytopenia. Extensive intraglomerular fibrin deposition was seen in a renal biopsy specimen. He was treated with corticosteroids, azathioprine, cyclophosphamide and hemodialysis with regional heparinization but not with systemic anticoagulation. This was followed by complete recovery of both renal function and histologic damage despite the fact that he did not receive anticoagulant therapy. This suggests that treatment with anticoagulants may not be necessary for all patients with intraglomerular deposits of fibrin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Colman R. W., Braun W. E., Busch G. J., Dammin G. J., Merrill J. P. Coagulation studies in the hyperacute and other forms of renal-allograft rejection. N Engl J Med. 1969 Sep 25;281(13):685–691. doi: 10.1056/NEJM196909252811301. [DOI] [PubMed] [Google Scholar]
  2. Gilchrist G. S., Lieberman E., Ekert H., Fine R. N., Grushkin C. Heparin therapy in the haemolytic-uraemic syndrome. Lancet. 1969 Jun 7;1(7606):1123–1126. doi: 10.1016/s0140-6736(69)91644-4. [DOI] [PubMed] [Google Scholar]
  3. Kaplan B. S., Katz J., Krawitz S., Lurie A. An analysis of the results of therapy in 67 cases of the hemolytic-uremic syndrome. J Pediatr. 1971 Mar;78(3):420–425. doi: 10.1016/s0022-3476(71)80221-4. [DOI] [PubMed] [Google Scholar]
  4. Kincaid-Smith P. Coagulation and renal disease. Kidney Int. 1972 Oct;2(4):183–190. doi: 10.1038/ki.1972.93. [DOI] [PubMed] [Google Scholar]
  5. Mathew T. H., Clyne D. H., Nanra R. S., Kincaid-Smith P., Saker B. M., Morris P. J., Marshall V. C. A controlled trial of oral anticoagulants and dipyridamole in cadaveric renal allografts. Lancet. 1974 Jun 29;1(7870):1307–1310. doi: 10.1016/s0140-6736(74)90680-1. [DOI] [PubMed] [Google Scholar]
  6. Pillay V. K., Kurtzman N. A., Manaligod J. R., Jonasson O. Selective thrombocytopenia due to localised microangiopathy of renal allografts. Lancet. 1973 Nov 3;302(7836):988–991. doi: 10.1016/s0140-6736(73)91088-x. [DOI] [PubMed] [Google Scholar]
  7. Tune B. M., Leavitt T. J., Gribble T. J. The hemolytic-uremic syndrome in California: a review of 28 nonheparinized cases with long-term follow-up. J Pediatr. 1973 Feb;82(2):304–310. doi: 10.1016/s0022-3476(73)80178-7. [DOI] [PubMed] [Google Scholar]
  8. Vitacco M., Sanchez Avalos J., Gianantonio C. A. Heparin therapy in the hemolytic-uremic syndrome. J Pediatr. 1973 Aug;83(2):271–275. doi: 10.1016/s0022-3476(73)80490-1. [DOI] [PubMed] [Google Scholar]
  9. Williams G. M., Hume D. M., Hudson R. P., Jr, Morris P. J., Kano K., Milgrom F. "Hyperacute" renal-homograft rejection in man. N Engl J Med. 1968 Sep 19;279(12):611–618. doi: 10.1056/NEJM196809192791201. [DOI] [PubMed] [Google Scholar]

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