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. 2001 Feb;85(2):191–195. doi: 10.1136/heart.85.2.191

Exercise capacity in adult patients with congenitally corrected transposition of the great arteries

P Fredriksen 1, A Chen 1, G Veldtman 1, S Hechter 1, J Therrien 1, G Webb 1
PMCID: PMC1729602  PMID: 11156671

Abstract

OBJECTIVE—To examine cardiopulmonary values, static lung function, and ejection fraction in adult patients with congenitally corrected transposition of the great arteries (CCTGA).
PATIENTS AND METHODS—41 patients who had undergone static lung function testing and cardiopulmonary exercise tests with measurements of ejection fraction were identified at the Toronto Congenital Cardiac Centre for Adults.
RESULTS—Aerobic capacity in patients with CCTGA was severely diminished, varying from 30-50% of the results achieved by healthy subjects. Normal values of right ventricular and left ventricular ejection fraction were found. However, the systemic right ventricular ejection fraction increased by 2% from rest to exercise, as opposed to the expected > 5% increase in a healthy population. The pulmonary left ventricular ejection fraction decreased by 2% at peak exercise.
CONCLUSION—Diminished values of heart rate, forced expiratory volume in one second (FEV1), forced vital capacity, and systolic blood pressure compared to the predicted values may contribute to the reduced maximal oxygen uptake (VO2max) found in patients with CCTGA. In addition, a limited increase in systolic right ventricular ejection fraction and a decrease in pulmonary left ventricle contractility suggest a dysfunction of both ventricles.


Keywords: aerobic capacity; ventricular dysfunction; lung function; congenitally corrected transposition of the great arteries

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Figure 1  .

Figure 1  

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Compared to median values of healthy subjects (both sexes) (13) patients with CCTGA show a diminished maximal oxygen uptake (VO2max) over all age groups.

Figure 2  .

Figure 2  

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Percent of predicted values (12) in CCTGA patients with regard to forced expiratory capacity (FVC) and forced expiratory volume in one second (FEV1).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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