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. 1979 Oct;38(1):64–69.

The progressive appearance of multiple urinary Bence-Jones proteins and serum paraproteins in a child with immune deficiency.

A C Bushell, J T Whicher, T Yuille
PMCID: PMC1537831  PMID: 118834

Abstract

Multiple urinary Bence-Jones proteins and serum paraproteins were found in a child with type I dysgammaglobulinaemia (Seligmann et al., 1968). These showed a continually evolving pattern over a period of 4 months in relation to systemic infections and with no evidence of underlying malignancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becroft D. M., Douglas R. Thymic alymphoplasia, monoclonal gammopathy, and Pneumocystis carinii pneumonia in an infant. Arch Dis Child. 1968 Aug;43(230):444–450. doi: 10.1136/adc.43.230.444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bruce R. M., Blaese R. M. Monoclonal gammopathy in the Wiskott-Aldrich syndrome. J Pediatr. 1974 Aug;85(2):204–207. doi: 10.1016/s0022-3476(74)80393-8. [DOI] [PubMed] [Google Scholar]
  3. Cawley L. P., Schenken J. R. Monoclonal hypergammaglobulinemia of the gamma M type in a nine-year-old girl with ataxia-telangiectasia. Am J Clin Pathol. 1970 Dec;54(6):790–801. doi: 10.1093/ajcp/54.6.790. [DOI] [PubMed] [Google Scholar]
  4. Cronstedt J., Carling L., Ostberg H. Idiopathic light chain dyscrasia--a new distinct entity? Report of a case. Acta Med Scand. 1974 Nov;196(5):445–447. doi: 10.1111/j.0954-6820.1974.tb01037.x. [DOI] [PubMed] [Google Scholar]
  5. Dammacco F., Waldenström J. Bence Jones proteinuria in benign monoclonal gammapathies. Incidence and characteristics. Acta Med Scand. 1968 Nov;184(5):403–409. doi: 10.1111/j.0954-6820.1968.tb02479.x. [DOI] [PubMed] [Google Scholar]
  6. Danon F., Seligmann M. Serum monoclonal immunoglobulins in childhood. Arch Dis Child. 1973 Mar;48(3):207–211. doi: 10.1136/adc.48.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. De Fazio S. R., Criswell B. S., Kimzey S. L., South M. A., Montgomery J. R. A paraprotein in severe combined immunodefeciency disease detected by immunoelectrophoretic analysis of plasma. Clin Exp Immunol. 1975 Mar;19(3):563–570. [PMC free article] [PubMed] [Google Scholar]
  8. Gale D. S., Versey J. M., Hobbs J. R. Rocket immunoselection for detection of heavy-chain diseases. Clin Chem. 1974 Oct;20(10):1292–1294. [PubMed] [Google Scholar]
  9. Harboe M., Pande H., Brandtzaeg P., Tveter K. J., Hjort P. F. Synthesis of donor type gamma-G-globulin following thymus transplantation in hypo-gamma-globulinaemia with severe lymphocytopenia. Scand J Haematol. 1966;3(5):351–374. doi: 10.1111/j.1600-0609.1966.tb02379.x. [DOI] [PubMed] [Google Scholar]
  10. Heremans J. F., Masson P. L. Specific analysis of immunoglobulins. Techniques and clinical value. Clin Chem. 1973 Mar;19(3):294–300. [PubMed] [Google Scholar]
  11. Kyle R. A., Maldonado J. E., Bayrd E. D. Idiopathic Bence Jones proteinuria--a distinct entity? Am J Med. 1973 Aug;55(2):222–226. doi: 10.1016/0002-9343(73)90172-1. [DOI] [PubMed] [Google Scholar]
  12. Radl J., Dooren L. H., Morell A., Skvaril F., Vossen J. M., Uittenbogaart C. H. Immunoglobulins and transient paraproteins in sera of patients with the Wiskott-Aldrich syndrome: a follow-up study. Clin Exp Immunol. 1976 Aug;25(2):256–263. [PMC free article] [PubMed] [Google Scholar]
  13. Ritchie R. F., Smith R. Immunofixation. III. Application to the study of monoclonal proteins. Clin Chem. 1976 Dec;22(12):1982–1985. [PubMed] [Google Scholar]
  14. Ritzmann S. E., Loukas D., Sakai H., Daniels J. C., Levin W. C. Idiopathic (asymptomatic) monoclonal gammopathies. Arch Intern Med. 1975 Jan;135(1):95–106. [PubMed] [Google Scholar]
  15. Rádl J., Dooren L. J., Eijsvoogel V. P., van Went J. J., Hijmans W. An immunological study during post-transplantation follow-up of a case of severe combined immunodeficiency. Clin Exp Immunol. 1972 Feb;10(2):367–382. [PMC free article] [PubMed] [Google Scholar]
  16. Rádl J., Masopust J., Houstek J., Hrodek O. Paraproteinaemia and unusual dys-gamma-globulinaemia in a case of Wiskott-Aldrich syndrome. An immunochemical study. Arch Dis Child. 1967 Dec;42(226):608–614. doi: 10.1136/adc.42.226.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. STOOP J. W., BALLIEUX R. E., WEYERS H. A. Paraproteinemia with secondary immune globulin deficiency in an infant. Pediatrics. 1962 Jan;29:97–104. [PubMed] [Google Scholar]
  18. Schaller J., Davis S. D., Ching Y. C., Lagunoff D., Williams C. P., Wedgwood R. J. Hypergammaglobulinaemia, antibody deficiency, autoimmune haemolytic anaemia, and nephritis in an infant with a familial lymphopenic immune defect. Lancet. 1966 Oct 15;2(7468):825–829. doi: 10.1016/s0140-6736(66)92255-0. [DOI] [PubMed] [Google Scholar]
  19. Schubert D., Cohn M. Immunoglobulin biosynthesis. 3. Blocks in defective synthesis. J Mol Biol. 1968 Dec;38(3):273–288. doi: 10.1016/0022-2836(68)90386-0. [DOI] [PubMed] [Google Scholar]
  20. Seligmann M., Fudenberg H. H., Good R. A. A proposed classification of primary immunologic deficiencies. Am J Med. 1968 Dec;45(6):817–825. doi: 10.1016/0002-9343(68)90180-0. [DOI] [PubMed] [Google Scholar]
  21. TAKATSUKI K., OSSERMAN E. F. DEMONSTRATION OF TWO TYPES OF LOW MOLECULAR WEIGHT GAMMA-GLOBULINS IN NORMAL HUMAN URINE. J Immunol. 1964 Jan;92:100–107. [PubMed] [Google Scholar]
  22. Young V. H. Transient paraproteins. Proc R Soc Med. 1969 Aug;62(8):778–780. doi: 10.1177/003591576906200805. [DOI] [PMC free article] [PubMed] [Google Scholar]

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