Abstract
Approximately 40% of gerbils subjected to one hour of unilateral carotid artery occlusion displayed neurological abnormalities during that time. Most such animals were subsequently found to have ischaemic neuronal alterations within the territory of the ipsilateral middle cerebral artery. In contrast, impaired reperfusion ('no-reflow') rarely occurred and cannot therefore be implicated in the pathogenesis of ischaemic brain damage.
Full text
PDF








Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ames A., 3rd, Wright R. L., Kowada M., Thurston J. M., Majno G. Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol. 1968 Feb;52(2):437–453. [PMC free article] [PubMed] [Google Scholar]
- Berry K., Wiśniewski H. M., Svarzbein L., Baez S. On the relationship of brain vasculature to production of neurological deficit and morphological changes following acute unilateral common carotid artery ligation in gerbils. J Neurol Sci. 1975 May;25(1):75–92. doi: 10.1016/0022-510x(75)90188-4. [DOI] [PubMed] [Google Scholar]
- Brown A. W., Brierley J. B. The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope. Br J Exp Pathol. 1968 Apr;49(2):87–106. [PMC free article] [PubMed] [Google Scholar]
- Cantu R. C., Ames A., 3rd, Di Giacinto G., Dixon J. Hypotension: a major factor limiting recovery from cerebral ischemia. J Surg Res. 1969 Sep;9(9):525–529. doi: 10.1016/0022-4804(69)90129-2. [DOI] [PubMed] [Google Scholar]
- Ginsberg M. D., Myers R. E. The topography of impaired microvascular perfusion in the primate brain following total circulatory arrest. Neurology. 1972 Oct;22(10):998–1011. doi: 10.1212/wnl.22.9.998. [DOI] [PubMed] [Google Scholar]
- Harrison M. J., Brownbill D., Lewis P. D., Russell R. W. Cerebral edema following carotid artery ligation in the gerbil. Arch Neurol. 1973 Jun;28(6):389–391. doi: 10.1001/archneur.1973.00490240049008. [DOI] [PubMed] [Google Scholar]
- Kahn K. The natural course of experimental cerebral infarction in the gerbil. Neurology. 1972 May;22(5):510–515. doi: 10.1212/wnl.22.5.510. [DOI] [PubMed] [Google Scholar]
- Kogure K., Busto R., Scheinberg P., Reinmuth O. M. Energy metabolites and water content in rat brain during the early stage of development of cerebral infarction. Brain. 1974 Mar;97(1):103–114. doi: 10.1093/brain/97.1.103. [DOI] [PubMed] [Google Scholar]
- Kogure K., Scheinberg P., Matsumoto A., Busto R., Reinmuth O. M. Catecholamines in experimental brain ischemia. Arch Neurol. 1975 Jan;32(1):21–24. doi: 10.1001/archneur.1975.00490430043005. [DOI] [PubMed] [Google Scholar]
- Levine S., Payan H. Effects of ischemia and other procedures on the brain and retina of the gerbil (Meriones unguiculatus). Exp Neurol. 1966 Nov;16(3):255–262. doi: 10.1016/0014-4886(66)90062-8. [DOI] [PubMed] [Google Scholar]
- Levine S., Sohn D. Cerebral ischemia in infant and adult gerbils. Relation to incomplete circle of Willis. Arch Pathol. 1969 Mar;87(3):315–317. [PubMed] [Google Scholar]
- Levy D. E., Brierley J. B. Communications between vertebro-basilar and carotid arterial circulations in the gerbil. Exp Neurol. 1974 Dec;45(3):503–508. doi: 10.1016/0014-4886(74)90155-1. [DOI] [PubMed] [Google Scholar]
- Levy D. E., Brierley J. B., Silverman D. G., Plum F. Brief hypoxia-ischemia initially damages cerebral neurons. Arch Neurol. 1975 Jul;32(7):450–456. doi: 10.1001/archneur.1975.00490490054004. [DOI] [PubMed] [Google Scholar]
- Little J. R., Kerr F. W., Sundt T. M., Jr Microcirculatory obstruction in focal cerebral ischemia. Relationship to neuronal alterations. Mayo Clin Proc. 1975 May;50(5):264–270. [PubMed] [Google Scholar]
- Salford L. G., Plum F., Brierley J. B. Graded hypoxia-oligemia in rat brain. II. Neuropathological alterations and their implications. Arch Neurol. 1973 Oct;29(4):234–238. doi: 10.1001/archneur.1973.00490280046006. [DOI] [PubMed] [Google Scholar]
- Salford L. G., Siesjö B. K. The influence of arterial hypoxia and unilateral carotid artery occlusion upon regional blood flow and metabolism in the rat brain. Acta Physiol Scand. 1974 Sep;92(1):130–141. doi: 10.1111/j.1748-1716.1974.tb05729.x. [DOI] [PubMed] [Google Scholar]





