Abstract
Population genetic studies, in Australian, Assamese, Cambodian, Chinese, Caucasian and Melanesian populations, were performed with several highly polymorphic DNA loci. Results showed that the Caucasian and Chinese had the highest level of heterozygosity. The size range of the majority of the polymorphic DNA fragments of a locus was the same in the different populations. The distinguishing feature of each ethnic group was the relative frequency of a particular set or group of alleles. For example, alleles >9.0 kb in size, in D14S13, or from 4.5 to 4.7 kb, in D18S27, were less than half as frequent in Caucasians than in the other populations. Overall, there were groups of alleles, at one or more loci, whose frequencies were different among some of the ethnic groups and therefore could be used to differentiate one group from the other.
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Selected References
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- Baird M., Balazs I., Giusti A., Miyazaki L., Nicholas L., Wexler K., Kanter E., Glassberg J., Allen F., Rubinstein P. Allele frequency distribution of two highly polymorphic DNA sequences in three ethnic groups and its application to the determination of paternity. Am J Hum Genet. 1986 Oct;39(4):489–501. [PMC free article] [PubMed] [Google Scholar]
- Balazs I., Baird M., Clyne M., Meade E. Human population genetic studies of five hypervariable DNA loci. Am J Hum Genet. 1989 Feb;44(2):182–190. [PMC free article] [PubMed] [Google Scholar]
- Chimera J. A., Harris C. R., Litt M. Population genetics of the highly polymorphic locus D16S7 and its use in paternity evaluation. Am J Hum Genet. 1989 Dec;45(6):926–931. [PMC free article] [PubMed] [Google Scholar]
- Deka R., Chakroborty R., Ferrell R. E. A population genetic study of six VNTR loci in three ethnically defined populations. Genomics. 1991 Sep;11(1):83–92. doi: 10.1016/0888-7543(91)90104-m. [DOI] [PubMed] [Google Scholar]
- Devlin B., Risch N., Roeder K. Estimation of allele frequencies for VNTR loci. Am J Hum Genet. 1991 Apr;48(4):662–676. [PMC free article] [PubMed] [Google Scholar]
- Devlin B., Risch N., Roeder K. No excess of homozygosity at loci used for DNA fingerprinting. Science. 1990 Sep 21;249(4975):1416–1420. doi: 10.1126/science.2205919. [DOI] [PubMed] [Google Scholar]
- Flint J., Boyce A. J., Martinson J. J., Clegg J. B. Population bottlenecks in Polynesia revealed by minisatellites. Hum Genet. 1989 Oct;83(3):257–263. doi: 10.1007/BF00285167. [DOI] [PubMed] [Google Scholar]
- Ip N. Y., van de Stadt I., Loewy Z. G., Leary S., Grzeschik K. H., Balazs I. Identification and characterization of a hypervariable region [D18S27] on chromosome 18. Nucleic Acids Res. 1989 Oct 25;17(20):8404–8404. doi: 10.1093/nar/17.20.8404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kasai K., Nakamura Y., White R. Amplification of a variable number of tandem repeats (VNTR) locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science. J Forensic Sci. 1990 Sep;35(5):1196–1200. [PubMed] [Google Scholar]
- Kidd J. R., Black F. L., Weiss K. M., Balazs I., Kidd K. K. Studies of three Amerindian populations using nuclear DNA polymorphisms. Hum Biol. 1991 Dec;63(6):775–794. [PubMed] [Google Scholar]
- Neuweiler J., Ruvolo V., Baum H., Grzeschik K. H., Balazs I. Isolation and characterization of a hypervariable region [D4S163] on chromosome 4. Nucleic Acids Res. 1990 Feb 11;18(3):691–691. doi: 10.1093/nar/18.3.691. [DOI] [PMC free article] [PubMed] [Google Scholar]