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. 1962 Aug;19(1):56–63. doi: 10.1111/j.1476-5381.1962.tb01426.x

On the mechanism of tachyphylaxis to tyramine in the isolated rat heart

J Axelrod, Edna Gordon, G Hertting, I J Kopin, L T Potter
PMCID: PMC1482244  PMID: 13863453

Abstract

Tyramine was shown to release [3H]-catecholamines from an isolated rat heart previously perfused with [3H]-noradrenaline. With successive injections of tyramine the amount of [3H]-catecholamine released fell progressively and there was a parallel decrease in the increment of amplitude and rate of contraction of the heart. Reserpinized hearts were shown to take up less [3H]-noradrenaline than normal hearts. Release of radioactivity and loss of responsiveness to tyramine occurred more rapidly in the reserpinized heart. In the same preparation the uptake of [14C]-tyramine exceeded the quantity of the noradrenaline released.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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