Abstract
The response of the isolated ileum of the guinea-pig to histamine is potentiated in the presence of 2-, 3- or 4-picolylamine. These compounds have been found to inhibit the histaminase and/or “diamine oxidase” of pig kidney. The three corresponding picolylmethylamines did not potentiate the response of the ileum to histamine; they were without significant affinity for the pig kidney oxidase. It is suggested that the potentiating action of the three primary amines is due to their inhibitory action on histaminase. The responses of the ileum to acetylcholine and 5-hydroxytryptamine were not potentiated.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ARUNLAKSHANA O., MONGAR J. L., SCHILD H. O. Potentiation of pharmacological effects of histamine by histaminase inhibitors. J Physiol. 1954 Jan;123(1):32–54. doi: 10.1113/jphysiol.1954.sp005032. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLASCHKO H., CHRUSCIEL T. L. Observations on the substrate specificity of aminne oxidases. Br J Pharmacol Chemother. 1959 Sep;14:364–367. doi: 10.1111/j.1476-5381.1959.tb00258.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLASCHKO H. The amine oxidases of mammalian blood plasma. Adv Comp Physiol Biochem. 1962;1:67–116. [PubMed] [Google Scholar]