Abstract
110 patients with uncomplicated gonococcal urethritis were treated with 2 g spectinomycin (Trobicin) intramuscularly. Seventy-five patients were available for follow-up and there was only one treatment failure, giving a cure rate of 98-6%. Of the 99 gonococcal isolates, 59 were sensitive to 5 microng/ml of spectinomycin or less and 40 were sensitive to 10 microng/ml. In a small sample of patients 2 g spectinomycin intramuscularly produced a serum concentration averaging 100 microng/ml after one hour.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Idsoe O., Guthe T., Willcox R. R., de Weck A. L. Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock. Bull World Health Organ. 1968;38(2):159–188. [PMC free article] [PubMed] [Google Scholar]
- Kousa M., Lassus A., Järveläinen R., Renkonen O. V. Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea in males and females. Br J Vener Dis. 1974 Aug;50(4):291–293. doi: 10.1136/sti.50.4.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LAIRD S. M., TAYLOR G. Treatment of gonorrhoea with actinospectacin. Br J Vener Dis. 1962 Jun;38:60–63. doi: 10.1136/sti.38.2.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Porter I. A., Wood W. J. Spectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae. Br J Vener Dis. 1974 Aug;50(4):289–290. doi: 10.1136/sti.50.4.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reyn A., Schmidt H., Trier M., Bentzon M. W. Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae. Br J Vener Dis. 1973 Feb;49(1):54–59. doi: 10.1136/sti.49.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stratigos J. D., Marsellou-Kinti O., Kassimatis V., Daikos G. K. Treatment of gonorrhoea with spectinomycin hydrochloride. Br J Vener Dis. 1973 Feb;49(1):60–61. doi: 10.1136/sti.49.1.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILLCOX R. R. ACTINOSPECTACIN (TROBICIN) IN THE TREATMENT OF GONORRHOEA. Acta Derm Venereol. 1963;43:399–404. [PubMed] [Google Scholar]
- Willcox R. R. Spectinomycin in the treatment of gonorrhoea in males. Br J Vener Dis. 1974 Aug;50(4):294–297. doi: 10.1136/sti.50.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]