Abstract
The effect of homograft sensitization of a mother against her fetuses has been studied. A female rabbit was repeatedly grafted from both members of a breeding pair. Their offspring should and do become objects of homograft sensitization induced in the female by grafts from the parents. After sensitization was established, fertilized ova were transplanted from the breeding pair to the sensitized female. At the same operation, an equal number of eggs was also transplanted to the same recipient from another breeding pair against which no sensitization had been induced. In 16 such families, the survival rates for offspring born of each type of egg were found to be almost identical, indicating that homograft sensitization in the mother directed against her fetuses did not demonstrably harm them.
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Selected References
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- BOYSE E. A., OLD L. J., STOCKERT E. Some further data on cytotoxic isoantibodies in the mouse. Ann N Y Acad Sci. 1962 Oct 24;99:574–587. doi: 10.1111/j.1749-6632.1962.tb45339.x. [DOI] [PubMed] [Google Scholar]
- BREYERE E. J., BARRETT M. K. "Tolerance" in postpartum female mice induced by strain-specific matings. J Natl Cancer Inst. 1960 Mar;24:699–705. doi: 10.1093/jnci/24.3.699. [DOI] [PubMed] [Google Scholar]
- DESAI R. G., CREGER W. P. Maternofetal passage of leukocytes and platelets in man. Blood. 1963 Jun;21:665–673. [PubMed] [Google Scholar]
- HULKA J. F., HSU K. C., BEISER S. M. Antibodies to trophoblasts during the post-partum period. Nature. 1961 Jul 29;191:510–511. doi: 10.1038/191510a0. [DOI] [PubMed] [Google Scholar]
- KALISS N., DAGG M. K., STIMPFLING J. H. MATERNAL TRANSFER OF ISOANTIBODY IN MICE. Transplantation. 1963 Oct;1:535–545. doi: 10.1097/00007890-196301040-00013. [DOI] [PubMed] [Google Scholar]
- LANMAN J. T., DINERSTEIN J., FIKRIG S. Homograft immunity in pregnancy: lack of harm to the fetus from sensitization of the mother. Ann N Y Acad Sci. 1962 Oct 24;99:706–716. doi: 10.1111/j.1749-6632.1962.tb45355.x. [DOI] [PubMed] [Google Scholar]
- MENGE A. C., KIDDY C. A., STONE W. H., CASIDA L. E. Immunological studies on fertility and sterility. V. Effect of antibodies against semen and erythrocytes on rabbit embryos. J Reprod Fertil. 1962 Aug;4:87–92. doi: 10.1530/jrf.0.0040087. [DOI] [PubMed] [Google Scholar]
- PEER L. A. Behavior of skin grafts exchanged between parents and offspring. Ann N Y Acad Sci. 1958 Oct 7;73(3):584–589. doi: 10.1111/j.1749-6632.1959.tb40836.x. [DOI] [PubMed] [Google Scholar]