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. 1978 May;5(5):421–424. doi: 10.1111/j.1365-2125.1978.tb01648.x

Effect of dopamine on airways conductance in normals and extrinsic asthmatics.

N C Thomson, K R Patel
PMCID: PMC1429342  PMID: 148897

Abstract

1 Specific conductance was measured before and after infused and/or inhaled dopamine in nine normal subjects and twelve patients with extrinsic bronchial asthma. 2 There was no significant change in conductance in either group. 3 The alpha-adrenergic receptor antagonist thymoxamine infused in combination with dopamine had no significant effect on conductance in three asthmatics. 4 It is concluded that dopamine has no acute effect on airways resistance and that specific dopamine receptors are unlikely to exist in human airways.

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Selected References

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  1. BLASCHKO H. Formation of catechol amines in the animal body. Br Med Bull. 1957 Sep;13(3):162–165. doi: 10.1093/oxfordjournals.bmb.a069606. [DOI] [PubMed] [Google Scholar]
  2. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dray A., Oakley N. R. Bromocriptine and dopamine-receptor stimulation. J Pharm Pharmacol. 1976 Jul;28(7):586–588. doi: 10.1111/j.2042-7158.1976.tb02802.x. [DOI] [PubMed] [Google Scholar]
  4. Eyre P. Release of dopamine from bovine lung by specific antigen and by compound 48-80. Br J Pharmacol. 1971 Jul;42(3):423–427. doi: 10.1111/j.1476-5381.1971.tb07127.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FALCK B., NYSTEDT T., ROSENGREN E., STENFLO J. DOPAMINE AND MAST CELLS IN RUMINANTS. Acta Pharmacol Toxicol (Copenh) 1964;21:51–58. doi: 10.1111/j.1600-0773.1964.tb01768.x. [DOI] [PubMed] [Google Scholar]
  6. Goldberg L. I. Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev. 1972 Mar;24(1):1–29. [PubMed] [Google Scholar]
  7. Greengard P. Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters. Nature. 1976 Mar 11;260(5547):101–108. doi: 10.1038/260101a0. [DOI] [PubMed] [Google Scholar]
  8. MCDONALD R. H., Jr, GOLDBERG L. I., MCNAY J. L., TUTTLE E. P., Jr EFFECT OF DOPAMINE IN MAN: AUGMENTATION OF SODIUM EXCRETION, GLOMERULAR FILTRATION RATE, AND RENAL PLASMA FLOW. J Clin Invest. 1964 Jun;43:1116–1124. doi: 10.1172/JCI104996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McNay J. L., Goldberg L. I. Comparison of the effects of dopamine, isoproterenol, norepinephrine and bradykinin on canine renal and femoral blood flow. J Pharmacol Exp Ther. 1966 Jan;151(1):23–31. [PubMed] [Google Scholar]
  10. Oldendorf W. H. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am J Physiol. 1971 Dec;221(6):1629–1639. doi: 10.1152/ajplegacy.1971.221.6.1629. [DOI] [PubMed] [Google Scholar]
  11. Patel K. R., Kerr J. W. The airways response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma. Clin Allergy. 1973 Dec;3(4):439–448. doi: 10.1111/j.1365-2222.1973.tb01351.x. [DOI] [PubMed] [Google Scholar]
  12. Prime F. J., Bianco S., Griffin J. P., Kamburoff P. L. The effects on airways conductance of alpha-adrenergic stimulation and blocking. Bull Physiopathol Respir (Nancy) 1972 Jan-Feb;8(1):99–109. [PubMed] [Google Scholar]
  13. Thorner M. O. Dopamine is an important neurotransmitter in the autonomic nervous system. Lancet. 1975 Mar 22;1(7908):662–665. doi: 10.1016/s0140-6736(75)91762-6. [DOI] [PubMed] [Google Scholar]
  14. VON EULER U. S., LISHAJKO F. Dopamine in mammalian lung and spleen. Acta Physiol Pharmacol Neerl. 1957;6:295–303. [PubMed] [Google Scholar]
  15. Whitsett T. L., Goldberg L. I. Effects of levodopa on systolic preejection period, blood pressure, and heart rate during acute and chronic treatment of Parkinson's disease. Circulation. 1972 Jan;45(1):97–106. doi: 10.1161/01.cir.45.1.97. [DOI] [PubMed] [Google Scholar]
  16. von Essen C. Effects of dopamine, noradrenaline and 5-hydroxytryptamine on the cerebral blood flow in the dog. J Pharm Pharmacol. 1972 Aug;24(8):668–668. doi: 10.1111/j.2042-7158.1972.tb09086.x. [DOI] [PubMed] [Google Scholar]

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