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. 1952 Mar 20;35(4):595–603. doi: 10.1085/jgp.35.4.595

HEMOLYSIS CONSIDERED AS A PROGRESSIVE REACTION IN A HETEROGENEOUS SYSTEM

Eric Ponder 1, R T Cox 1
PMCID: PMC2147313  PMID: 14898037

Abstract

It is demonstrated, without the use of special assumptions, that red cells are heterogeneous with respect to their resistance to at least certain lysins, that the reaction between the cell components and the lysin is virtually irreversible in some cases but reversible, although to different extents, in others, and that the lysin initiates a process in the cell which is not adequately described by the terms reversible and irreversible, but rather by the term progressive. Progressive reactions, i.e. reactions which cannot be stopped once they are well under way, may be looked for in systems which have structure, and in which local reactions occurring at strategic points lead to disproportionate results.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBERTY R. A., BALDWIN R. L. A mathematical theory of immune hemolysis. J Immunol. 1951 Jun;66(6):725–735. [PubMed] [Google Scholar]

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