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. 1978 Mar;31(3):391–396.

Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome.

C P Worman, G F Burns, C R Barker
PMCID: PMC1541259  PMID: 148985

Abstract

It has been demonstrated that in two patients with T-cell Sézary syndrome the pathological cells express a receptor for EA(IgM) when cultured in a medium with foetal calf or autologous serum. A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-rosetting cells progressively expressed this receptor. In agreement with previous reports by others on the normal T-cell population bearing the IgM receptor, incubation at 37 degrees C in the presence of serum was shown to be a necessary condition. The implications of this pathological subpopulation of T-cells are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Braylan R., Variakojis D., Yachnin S. The Sézary syndrome lymphoid cell: abnormal surface properties and mitogen responsiveness. Br J Haematol. 1975 Dec;31(4):553–564. doi: 10.1111/j.1365-2141.1975.tb00890.x. [DOI] [PubMed] [Google Scholar]
  2. Broder S., Edelson R. L., Lutzner M. A., Nelson D. L., MacDermott R. P., Durm M. E., Goldman C. K., Meade B. D., Waldmann T. A. The Sézary syndrome: a malignant proliferation of helper T cells. J Clin Invest. 1976 Dec;58(6):1297–1306. doi: 10.1172/JCI108585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burns G. F., Cawley J. C., Barker C. R., Goldstone A. H., Hayhoe F. G. New evidence relating to the nature and origin of the hairy cell of leukaemic reticuloendotheliosis. Br J Haematol. 1977 May;36(1):71–84. doi: 10.1111/j.1365-2141.1977.tb05757.x. [DOI] [PubMed] [Google Scholar]
  4. Conradie J. D., Bubb M. O. Cmu4 domain of IgM has cytophilic activity for human lymphocytes. Nature. 1977 Jan 13;265(5590):160–161. doi: 10.1038/265160a0. [DOI] [PubMed] [Google Scholar]
  5. Edelson R. L., Kirkpatrick C. H., Shevach E. M., Schein P. S., Smith R. W., Green I., Lutzner M. Preferential cutaneous infiltration by neoplastic thymus-derived lymphocytes. Morphologic and functional studies. Ann Intern Med. 1974 Jun;80(6):685–692. doi: 10.7326/0003-4819-80-6-685. [DOI] [PubMed] [Google Scholar]
  6. Hallberg T., Gurner B. W., Coombs R. R. Opsonic adherence of sensitized ox red cells to human lymphocytes as measured by rosette formation. Int Arch Allergy Appl Immunol. 1973;44(4):500–513. doi: 10.1159/000230956. [DOI] [PubMed] [Google Scholar]
  7. Kaplan M. E., Clark C. An improved rosetting assay for detection of human T lymphocytes. J Immunol Methods. 1974 Jul;5(2):131–135. doi: 10.1016/0022-1759(74)90003-9. [DOI] [PubMed] [Google Scholar]
  8. Lamon E. W., Whitten H. D., Skurzak H. M., Andersson B., Lidin B. IgM antibody-dependent cell-mediated cytotoxicity in the Moloney sarcoma virus system: the involvement of T and B lymphocytes as effector cells. J Immunol. 1975 Nov;115(5):1288–1294. [PubMed] [Google Scholar]
  9. McConnell I., Hurd C. M. Lymphocyte receptors. II. Receptors for rabbit IgM on human T lymphocytes. Immunology. 1976 Jun;30(6):835–839. [PMC free article] [PubMed] [Google Scholar]
  10. Moretta L., Ferrarini M., Durante M. L., Mingari M. C. Expression of a receptor for IgM by human T cells in vitro. Eur J Immunol. 1975 Aug;5(8):565–569. doi: 10.1002/eji.1830050812. [DOI] [PubMed] [Google Scholar]
  11. Moretta L., Ferrarini M., Mingari M. C., Moretta A., Webb S. R. Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness. J Immunol. 1976 Dec;117(6):2171–2174. [PubMed] [Google Scholar]
  12. Moretta L., Mingari M. C., Moretta A., Lydyard P. M. Receptors for IgM are expressed on acute lymphoblastic leukemic cells having T-cell characteristics. Clin Immunol Immunopathol. 1977 May;7(3):405–409. doi: 10.1016/0090-1229(77)90075-7. [DOI] [PubMed] [Google Scholar]
  13. Ramasamy R. A fluorescent stain for viable rosette-forming cells. J Immunol Methods. 1974 Aug;5(3):305–306. doi: 10.1016/0022-1759(74)90116-1. [DOI] [PubMed] [Google Scholar]
  14. Sheldon P. J., Holborow E. J. H-rosette formation in T-cell-proliferative diseases. Br Med J. 1975 Nov 15;4(5993):381–383. doi: 10.1136/bmj.4.5993.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Smith J. L., Clein G. P., Barker C. R., Collins R. D. Characterisation of malignant mediastinal lymphoid neoplasm (Sternberg sarcoma) as thymic in origin. Lancet. 1973 Jan 13;1(7794):74–77. doi: 10.1016/s0140-6736(73)90469-8. [DOI] [PubMed] [Google Scholar]
  16. Toben H. R., Smith R. G. T lymphocytes bearing complement receptors in a patient with chronic lymphocytic leukaemia. Clin Exp Immunol. 1977 Feb;27(2):292–302. [PMC free article] [PubMed] [Google Scholar]
  17. Wybran J., Fudenberg H. H. Thymus-derived rosette-forming cells. N Engl J Med. 1973 May 17;288(20):1072–1073. doi: 10.1056/NEJM197305172882011. [DOI] [PubMed] [Google Scholar]
  18. Zucker-Franklin D., Melton J. W., 3rd, Quagliata F. Ultrastructural, immunologic, and functional studies on Sézary cells: a neoplastic variant of thymus-derived (T) lymphocytes. Proc Natl Acad Sci U S A. 1974 May;71(5):1877–1881. doi: 10.1073/pnas.71.5.1877. [DOI] [PMC free article] [PubMed] [Google Scholar]

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