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. 2004 Dec;24(6):707–728. doi: 10.1007/s10571-004-6913-z

Pharmacological and Biochemical Aspects of GABAergic Neurotransmission: Pathological and Neuropsychobiological Relationships

Renê Oliveira Beleboni 1, Ruither Oliveira Gomes Carolino 1, Andrea Baldocchi Pizzo 2, Lissandra Castellan-Baldan 3, Joaquim Coutinho-Netto 1, Wagner Ferreira dos Santos 2, Norberto Cysne Coimbra 3,✉
PMCID: PMC11529967  PMID: 15672674

Abstract

1. The GABAergic neurotransmission has been implicated in the modulation of many neural networks in forebrain, midbrain and hindbrain, as well as, in several neurological disorders.

2. The complete comprehension of GABA system neurochemical properties and the search for approaches in identifying new targets for the treatment of neural diseases related to GABAergic pathway are of the extreme relevance.

3. The present review will be focused on the pharmacology and biochemistry of the GABA metabolism, GABA receptors and transporters. In addition, the pathological and psychobiological implications related to GABAergic neurotransmission will be considered.

Keywords: GABAergic neurotransmission, GABA receptors, GABA transaminase, GABA transporters, defensive behavior

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