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Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1975 Jul;39(3):305–309.

Effect of pasteurization and evaporation on foot-and-mouth disease virus in whole milk from infected cows.

J L Hyde, J H Blackwell, J J Callis
PMCID: PMC1277462  PMID: 166740

Abstract

The effects of pasteurization and evaporation on foot-and-mouth disease virus in whole milk from infected cows obtained one day postinoculation were studied. Virus survived the heating of milk at high temperature-short time pasteurization at 75 degrees C for 15-17 seconds. In addition, virus from infected milk survived heating at 80 degrees C for the same time. Infective virus also survived in the pasteurized milk after evaporation at 65 degrees C to 50% of the original volume. The bovine udder was found to be highly susceptible to foot-and-mouth disease virus replication. Seven log10 plaque-forming units/ml of virus were recovered in whole milk 24 hours postinoculation, and decreasing titers were recovered for as long as seven days postinoculation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BACHRACH H. L., BREESE S. S., Jr, CALLIS J. J., HESS W. R., PATTY R. E. Inactivation of foot-and-mouth disease virus by pH and temperature changes and by formaldehyde. Proc Soc Exp Biol Med. 1957 May;95(1):147–152. doi: 10.3181/00379727-95-23148. [DOI] [PubMed] [Google Scholar]
  2. BACHRACH H. L., CALLIS J. J., HESS W. R., PATTY R. E. A plaque assay for foot-and-mouth disease virus and kinetics of virus reproduction. Virology. 1957 Oct;4(2):224–236. doi: 10.1016/0042-6822(57)90060-0. [DOI] [PubMed] [Google Scholar]
  3. BACHRACH H. L., PATTY R. E., PLEDGER R. A. Thermal-resistant populations of foot-and-mouth disease virus. Proc Soc Exp Biol Med. 1960 Mar;103:540–542. doi: 10.3181/00379727-103-25588. [DOI] [PubMed] [Google Scholar]
  4. BACHRACH H. L. Thermal degradation of foot-and-mouth disease virus into infectious ribonucleic acid. Proc Soc Exp Biol Med. 1961 Jul;107:610–613. doi: 10.3181/00379727-107-26703. [DOI] [PubMed] [Google Scholar]
  5. Burrows R., Mann J. A., Greig A., Chapman W. G., Goodridge D. The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland. J Hyg (Lond) 1971 Jun;69(2):307–321. doi: 10.1017/s0022172400021537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cowan K. M., Trautman R. Immunochemical studies of foot and mouth disease. I. Complement fixation reactions with isolated antigenic components. J Immunol. 1967 Oct;99(4):729–736. [PubMed] [Google Scholar]
  7. Dawson P. S. The involvement of milk in the spread of foot-and-mouth disease: an epidemiological study. Vet Rec. 1970 Oct 31;87(18):543–548. doi: 10.1136/vr.87.18.543. [DOI] [PubMed] [Google Scholar]
  8. Graves J. H., McVicar J. W., Sutmoller P., Trautman R. Contact transmission of foot-and-mouth disease from infected to susceptible cattle. J Infect Dis. 1971 Apr;123(4):386–391. doi: 10.1093/infdis/123.4.386. [DOI] [PubMed] [Google Scholar]
  9. Hedger R. S., Dawson P. S. Foot-and-mouth disease virus in milk: an epidemiological study. Vet Rec. 1970 Aug 15;87(7):186–passim. doi: 10.1136/vr.87.7.186. [DOI] [PubMed] [Google Scholar]
  10. KAPLAN A. S., MELNICK J. L. Effect of milk and cream on the thermal inactivation of human poliomyelitis virus. Am J Public Health Nations Health. 1952 May;42(5 Pt 1):525–534. doi: 10.2105/ajph.42.5_pt_1.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KAPLAN A. S., MELNICK J. L. Effect of milk and other dairy products on the thermal inactivation of Coxsackie viruses. Am J Public Health Nations Health. 1954 Sep;44(9):1174–1184. doi: 10.2105/ajph.44.9.1174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sellers R. F. Inactivation of foot-and-mouth disease virus in milk. Br Vet J. 1969 Apr;125(4):163–168. doi: 10.1016/s0007-1935(17)49008-7. [DOI] [PubMed] [Google Scholar]
  13. Sullivan R., Tierney J. T., Larkin E. P., Read R. B., Jr, Peeler J. T. Thermal resistance of certain oncogenic viruses suspended in milk and milk products. Appl Microbiol. 1971 Sep;22(3):315–320. doi: 10.1128/am.22.3.315-320.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

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