Abstract
Thirty-eight mutations in 13 essential loci in the zeste-white region were tested for interacting maternal and zygotic gene activity. Maternal mutant heterozygosity provided a partial maternal defect and position-effect variegation was used to alter the level of zygotic gene activity. This method yields a minimum estimate of the number of genes for which zygotic development depends upon both gene products stored in the egg and gene products synthesized in the zygote. Lethal interactions were found for one or more alleles at 10 of the 13 loci. The implications of these observations with respect to gene regulation and developmental sequence are considered.
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- Baker W. K. A genetic framework for Drosophila development. Annu Rev Genet. 1978;12:451–470. doi: 10.1146/annurev.ge.12.120178.002315. [DOI] [PubMed] [Google Scholar]
- Davidson E. H., Hough-Evans B. R., Britten R. J. Molecular biology of the sea urchin embryo. Science. 1982 Jul 2;217(4554):17–26. doi: 10.1126/science.6178156. [DOI] [PubMed] [Google Scholar]
- Gehring W. J. Developmental genetics of Drosophila. Annu Rev Genet. 1976;10:209–252. doi: 10.1146/annurev.ge.10.120176.001233. [DOI] [PubMed] [Google Scholar]
- Judd B. H., Shen M. W., Kaufman T. C. The anatomy and function of a segment of the X chromosome of Drosophila melanogaster. Genetics. 1972 May;71(1):139–156. doi: 10.1093/genetics/71.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lim J. K., Snyder L. A. Cytogenetic and complementation analyses of recessive lethal mutations induced in the X chromosome of Drosophila by three alkylating agents. Genet Res. 1974 Aug;24(1):1–10. doi: 10.1017/s0016672300015020. [DOI] [PubMed] [Google Scholar]
- Lindsley D. L., Sandler L., Baker B. S., Carpenter A. T., Denell R. E., Hall J. C., Jacobs P. A., Miklos G. L., Davis B. K., Gethmann R. C. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972 May;71(1):157–184. doi: 10.1093/genetics/71.1.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ouweneel W. J. Developmental genetics of homoeosis. Adv Genet. 1976;18:179–248. doi: 10.1016/s0065-2660(08)60439-3. [DOI] [PubMed] [Google Scholar]
- Robbins L. G. Maternal-zygotic lethal interactions in Drosophila melanogaster: the effects of deficiencies in the zeste-white region of the X chromosome. Genetics. 1980 Sep;96(1):187–200. doi: 10.1093/genetics/96.1.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robbins L. G. The meiotic effect of a deficiency in Drosophila melanogaster with a model for the effects of enzyme deficiency on recombination. Genetics. 1977 Dec;87(4):655–684. doi: 10.1093/genetics/87.4.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shannon M. P., Kaufman T. C., Shen M. W., Judd B. H. Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. Genetics. 1972 Dec;72(4):615–638. doi: 10.1093/genetics/72.4.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Suzuki D. T. Temperature-sensitive mutations in Drosophila melanogaster. Science. 1970 Nov 13;170(3959):695–706. doi: 10.1126/science.170.3959.695. [DOI] [PubMed] [Google Scholar]
- Thierry-Mieg D. Paralog, a control mutant in Drosophila melanogaster. Genetics. 1982 Feb;100(2):209–237. doi: 10.1093/genetics/100.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]