Abstract
With the aim of testing the validity of the mutation-drift hypothesis, we examined the pattern of genetic differentiation between populations by using data from Drosophila, fishes, reptiles, and mammals. The observed relationship between genetic identity and correlation of heterozygosities of different populations or species was generally in good agreement with the theoretical expectations from the mutation-drift theory, when the variation in mutation rate among loci was taken into account. In some species of Drosophila, however, the correlation was unduly high. The relationship between the mean and variance of genetic distance was also in good agreement with the theoretical prediction in almost all organisms. We noted that both the distribution of heterozygosity within species and the pattern of genetic differentiation between species can be explained by the same set of genetic parameters in each group of organisms. Alternative hypotheses for explaining these observations are discussed.
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Selected References
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- Fuerst P. A., Chakraborty R., Nei M. Statistical studies on protein polymorphism in natural populations. I. Distribution of single locus heterozygosity. Genetics. 1977 Jun;86(2 Pt 1):455–483. [PMC free article] [PubMed] [Google Scholar]
- Gillespie J. H., Langley C. H. A general model to account for enzyme variation in natural populations. Genetics. 1974 Apr;76(4):837–848. doi: 10.1093/genetics/76.4.837. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnson G. B. Enzyme polymorphism and metabolism. Science. 1974 Apr 5;184(4132):28–37. doi: 10.1126/science.184.4132.28. [DOI] [PubMed] [Google Scholar]
- Li W. H., Nei M. Drift variances of heterozygosity and genetic distance in transient states. Genet Res. 1975 Jun;25(3):229–248. doi: 10.1017/s0016672300015664. [DOI] [PubMed] [Google Scholar]
- McDermid E. M., Bonner W. N. Red cell and serum protein systems of grey seals and habour seals. Comp Biochem Physiol B. 1975 Jan 15;50(1):97–101. doi: 10.1016/0305-0491(75)90306-5. [DOI] [PubMed] [Google Scholar]
- Nei M., Chakraborty R., Fuerst P. A. Infinite allele model with varying mutation rate. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4164–4168. doi: 10.1073/pnas.73.11.4164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nei M., Fuerst P. A., Chakraborty R. Testing the neutral mutation hypothesis by distribution of single locus heterozygosity. Nature. 1976 Aug 5;262(5568):491–493. doi: 10.1038/262491a0. [DOI] [PubMed] [Google Scholar]
- Nei M., Roychoudhury A. K. Genic variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids. Am J Hum Genet. 1974 Jul;26(4):421–443. [PMC free article] [PubMed] [Google Scholar]
- Ohta T., Kimura M. A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res. 1973 Oct;22(2):201–204. doi: 10.1017/s0016672300012994. [DOI] [PubMed] [Google Scholar]