Abstract
This study was set up to investigate whether work as a stoker is associated with an increased risk of specific malignant neoplasms. For this purpose, a cohort of 2777 male stokers was followed up through a 10 year period with regard to cause specific mortality. Comparisons were made with another cohort of unskilled male workers in physically demanding jobs. The mortality of the stokers was significantly increased for lung cancer (standardised mortality ratio (SMR) 145, 95% confidence interval (95% CI) 110-186) and for multiple myeloma (SMR 388, 95% CI 106-994). Also, increases were seen for cancer of the urinary organs and cancer of the mouth and throat. The combustion products to which the stokers have been exposed comprise several carcinogenic agents including polycyclic aromatic hydrocarbons, benzene, arsenic, and radionuclides. It seems likely that the occupational exposure of stokers has contributed to their excess cancer mortality.
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Selected References
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- Aksoy M. Malignancies due to occupational exposure to benzene. Am J Ind Med. 1985;7(5-6):395–402. doi: 10.1002/ajim.4700070506. [DOI] [PubMed] [Google Scholar]
- Alfheim I., Bergström J. G., Jenssen D., Møller M. Mutagenicity in emissions from coal- and oil-fired boilers. Environ Health Perspect. 1983 Jan;47:177–187. doi: 10.1289/ehp.8347177. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Axelson O., Dahlgren E., Jansson C. D., Rehnlund S. O. Arsenic exposure and mortality: a case-referent study from a Swedish copper smelter. Br J Ind Med. 1978 Feb;35(1):8–15. doi: 10.1136/oem.35.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boffetta P., Stellman S. D., Garfinkel L. A case-control study of multiple myeloma nested in the American Cancer Society prospective study. Int J Cancer. 1989 Apr 15;43(4):554–559. doi: 10.1002/ijc.2910430404. [DOI] [PubMed] [Google Scholar]
- Cuzick J., De Stavola B. Multiple myeloma--a case-control study. Br J Cancer. 1988 May;57(5):516–520. doi: 10.1038/bjc.1988.118. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cuzick J. Radiation-induced myelomatosis. N Engl J Med. 1981 Jan 22;304(4):204–210. doi: 10.1056/NEJM198101223040404. [DOI] [PubMed] [Google Scholar]
- Decouflé P., Blattner W. A., Blair A. Mortality among chemical workers exposed to benzene and other agents. Environ Res. 1983 Feb;30(1):16–25. doi: 10.1016/0013-9351(83)90161-5. [DOI] [PubMed] [Google Scholar]
- Doll R., Peto R. Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J. 1976 Dec 25;2(6051):1525–1536. doi: 10.1136/bmj.2.6051.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doll R., Vessey M. P., Beasley R. W., Buckley A. R., Fear E. C., Fisher R. E., Gammon E. J., Gunn W., Hughes G. O., Lee K. Mortality of gasworkers - final report of a prospective study. Br J Ind Med. 1972 Oct;29(4):394–406. doi: 10.1136/oem.29.4.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fisher G. L. Biomedically relevant chemical and physical properties of coal combustion products. Environ Health Perspect. 1983 Jan;47:189–199. doi: 10.1289/ehp.8347189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Flodin U., Fredriksson M., Persson B. Multiple myeloma and engine exhausts, fresh wood, and creosote: a case-referent study. Am J Ind Med. 1987;12(5):519–529. doi: 10.1002/ajim.4700120506. [DOI] [PubMed] [Google Scholar]
- Gustavsson P., Reuterwall C. Mortality and incidence of cancer among Swedish gas workers. Br J Ind Med. 1990 Mar;47(3):169–174. doi: 10.1136/oem.47.3.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harris C. C., Vahakangas K., Newman M. J., Trivers G. E., Shamsuddin A., Sinopoli N., Mann D. L., Wright W. E. Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci U S A. 1985 Oct;82(19):6672–6676. doi: 10.1073/pnas.82.19.6672. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haugen A., Becher G., Benestad C., Vahakangas K., Trivers G. E., Newman M. J., Harris C. C. Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere. Cancer Res. 1986 Aug;46(8):4178–4183. [PubMed] [Google Scholar]
- Ichimaru M., Ishimaru T., Mikami M., Matsunaga M. Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950-76: relationship to radiation dose absorbed by marrow. J Natl Cancer Inst. 1982 Aug;69(2):323–328. [PubMed] [Google Scholar]
- Krøkje A. Mutagenicity of expectorate from workers in a coke plant. Mutat Res. 1989 Jun;223(2):213–219. doi: 10.1016/0165-1218(89)90049-9. [DOI] [PubMed] [Google Scholar]
- La Vecchia C., Negri E., D'Avanzo B., Franceschi S. Occupation and lymphoid neoplasms. Br J Cancer. 1989 Sep;60(3):385–388. doi: 10.1038/bjc.1989.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miner J. K., Rom W. N., Livingston G. K., Lyon J. L. Lymphocyte sister chromatid exchange (SCE) frequencies in coke oven workers. J Occup Med. 1983 Jan;25(1):30–33. doi: 10.1097/00043764-198301000-00012. [DOI] [PubMed] [Google Scholar]
- Morris P. D., Koepsell T. D., Daling J. R., Taylor J. W., Lyon J. L., Swanson G. M., Child M., Weiss N. S. Toxic substance exposure and multiple myeloma: a case-control study. J Natl Cancer Inst. 1986 Jun;76(6):987–994. [PubMed] [Google Scholar]
- Szyja J. Untersuchungen über den 3,4-Benzypyrengehalt an Arbeitsplätzen der Pechofenbatterie einer Kokerei und in Körperflüssigkeiten der Arbeiter. Z Gesamte Hyg. 1977 Jul;23(7):440–442. [PubMed] [Google Scholar]
- Torres A., Giralt M., Raichs A. Coexistencia de antecedentes benzólicos crónicos y plasmocitoma múltiple. Presentación de dos casos. Sangre (Barc) 1970;15(2):275–279. [PubMed] [Google Scholar]