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. 1992 Mar;66(3):1799–1803. doi: 10.1128/jvi.66.3.1799-1803.1992

Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.

W R Lee 1, X F Yu 1, W J Syu 1, M Essex 1, T H Lee 1
PMCID: PMC240944  PMID: 1738209

Abstract

Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.

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Selected References

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