Release of ischaemia prior to wound closure in total knee arthroplasty: a better method?

Abstract

We included 46 total knee arthroplasties (43 patients) in a prospective, randomised study, dividing them into two groups: group A (23 knees, 21 patients) in which the ischaemia was released prior to wound closure allowing control of bleeding and group B (23 knees, 22 patients) releasing the tourniquet after suturing and bandaging. We compared the haemoglobin before surgery and at 24 and 48 h postoperatively, the total blood loss and the transfusions that were needed. Student's t-test was used to analyse the data. The results we obtained were as follows: preoperative haemoglobin in group A was 14.21 g/dl and group B 14.28 g/dl; haemoglobin at 24/48 h for group A was 10.04/10.1 g/dl and group B 10.28/10.3 g/dl; total blood loss was 743.2 cc for group A and 692.5 cc for group B; the mean number of blood units transfused were 2 in group A and 1.8 in group B. No statistical differences were found in the data analysed, but one of the complications in group B was major blood loss right after surgery that needed reintervention. We assume that this could have been avoided if the tourniquet had been released beforehand. We conclude that releasing ischaemia prior to wound closure does not demonstrate a statistical difference, but like other authors, we found clinical advantages suggesting the need of further study of this situation.

Introduction

Most orthopaedic surgeons use ischaemia for total knee arthroplasties with the obvious advantage of a bloodless field, making it easier to place the implants and obtain a better cement-bone interface [1, 19]. The use of a tourniquet for long periods of time is associated with nerve paralysis and more postoperative pain [2]; this is why new methods are being investigated to allow a clean surgical field without the complications caused by the use of ischaemia for a long period of time [4]. The pressure used in the tourniquet should be enough to stop bleeding in the surgical field [11], but not excessive, which would increase postoperative pain [15, 21].

Epinephrine-augmented hypotensive epidural anaesthesia and tranexamic acid are some alternatives used to avoid ischaemia, but they are still under investigation, and their use has not been generalised [5, 9, 13]. Tranexamic acid acts by binding to one of the enzymes at the start of the coagulation cascade inhibiting the fibrinolytic system resulting in less blood loss. It is of concern that this inhibition might cause an increase in thrombosis [17].

Haemostasis is important in total knee arthroplasties due to the potential for major blood loss. The purpose of this study was to demonstrate the benefits of an early release of ischaemia in these operations.

Patients and methods

This was a prospective, randomised study that took place from December 2004 to December 2005. We included 43 patients (46 total knee arthroplasties), 13 males (30%) and 30 females (70%), dividing them into two groups: group A (23 knees, 21 patients), in which the ischaemia was released prior to wound closure allowing control of bleeding, and group B (23 knees, 22 patients) releasing the tourniquet after suturing and bandaging. The patients were assigned in random order to each group according to the moment of intervention. Inclusion criteria were patients with the diagnosis of knee arthrosis undergoing a primary total knee arthroplasty; we excluded patients with a revision knee arthroplasty, arthrosis caused by a previous fracture, rheumatoid arthritis and patients with anticoagulation therapy 6 months prior to intervention. Every patient signed an informed consent before being included in the study.

Three surgeons participated in the procedures. One gram of cephalothin was given IV at anaesthesia induction and continued every 8 h for the next 24 h. Clindamycin was used for patients allergic to beta-lactam agents, giving 600 mg IV at anaesthesia induction, followed by the same dosage every 12 h for the next 24 h. For pain control we used 40 mg of parecoxib administered IV every 12 h combined with ketorolac 30 mg IV every 8 h or as an alternative clonixinate of lisine 100 mg IV every 6 h. Anticoagulation prophylaxis was carried out with 40 mg of enoxaparin administered subcutaneously every 24 h and compressive stockings until active mobilisation of the patient.

Student's t-test was used to analyse the data.

Operative technique

Before surgery a tourniquet cuff was placed on the upper half of the thigh and the limb was exsanguinated by elevation and compressive bandaging. The cuff was then inflated 100 mmHg above median arterial pressure. The knee was exposed through a midline skin incision and a deep medial parapatellar approach with a conventional capsulotomy. The prostheses that were implanted were: Scorpio (Stryker, Mahwah, NJ), Sulzer Medica (Protek, Austin, TX) and Depuy (Johnson & Johnson, Warsaw, IN); the sizes are mentioned in Table 1.

Table 1.

Prostheses components

Brand	Femur	Tibia	Patella	Insert
Group A
Scorpio	N°11-1 com.	N°11-1 com.	N°5-1 com.	15 mm-2 com.
14 prostheses (61%)	N°9-5 com.	N°9-3 com.	W/O-13	13 mm-3 com.
	N°7-7 com.	N°7-7 com.	—–	12 mm-3 com.
	N°5-1 com.	N°5-3 com.	—–	10 mm-6 com.
S. Medica	N°2-7 com.	N°2-7 com.	N°2-4 com.	9 mm-5 com.
9 prosthesis (39%)	N°1-2 com.	N°1-2 com.	N° 1-5 com.	8 mm-4 com.
Group B
Scorpio	N°13-2 com.	N°11-3 com.	W/O-15	12 mm-4 com.
15 prostheses (65%)	N°11-3 com.	N°9-5 com.	—–	11 mm-2 com.
	N°9-3 com.	N°7-4 com.	—–	10 mm-9 com.
	N°7-5 com.	N°2-3 com.	—–	9 mm-6 com.
	N°5-2 com	—–	—–	8 mm-2 com.
S. Medica	N°2-2 com.	N°3-7 com.	N°1-7 com.
7 prostheses (31%)	N°1-5 com.	—–	—–
Depuy	N°3-1 com.	N°3-1 com.	W/O-1
1 prosthesis (4%)

W/O = without a patellar component

Com = component(s)

Before surgical wound closure, a large suction drain was placed intrarticularly. When the drainage was less than 20 cc in 24 h the suction drain was removed. The transoperative blood loss, surgical time and amount of the drainage were recorded. We compared the haemoglobin before surgery and at 24 and 48 h postoperatively, the total blood loss and the transfusions that were needed. Transfusions were given to patients with haemoglobin under 9 g/dl.

Results

The two groups were similar in age, preoperative haemoglobin (P = 0.2), prostheses and total blood loss (P = 0.2) (Table 2). The time of removal of the drain did not demonstrate statistical diferences between the two groups.

Table 2.

Clinical features of both groups

	Mean	Range	Statistical value
Group A
Age (years)	75.9	51–86	—
Preop Hb (g/dl)	14.2	11.7–17.4	P=0.2
Total BL (cc)	743.2	270–1,485	P=0.2
Group B
Age (years)	76	55–85	—
Preop Hb (g/dl)	14.2	12.8–17.1	P=0.2
Total BL (cc)	692.5	218–1,830	P=0.2

BL= blood loss

Preoperative haemoglobin was similar, in group A 14.21 g/dl and group B 14.28 g/dl, with a statistical value of P=0.2 (Table 2).

The average total blood loss (transoperative blood loss + postoperative drainage) obtained was of 743.2 cc (range 270–1,485) for group A and 692.5 cc (range 218–1,830) for group B, with a statistical value of P=0.2 (Table 2).

Haemoglobin at 24 h for group A was an average of 10.04 g/dl (range 7.6–13.9) and group B 10.28 g/dl (range 7.4–12.4), without finding a statistical difference of P=0.2 (Table 3). For haemoglobin at 48 h, the average was 10.1 g/dl (range 7.4–14.0) for group A and 10.3 g/dl (range 8.2–12.9) for group B without a statistical difference (P = 0.2) (Table 3).

Table 3.

Clinical features of both groups

	Mean	Range	Statistical value
Group A
Hb at 24 h (g/dl)	10.04	7.6–13.9	P=0.2
Hb at 48 h (g/dl)	10.1	7.4–14.0	P=0.2
BU transfused	2	0–5	P=0.2
Group B
Hb at 24 h (g/dl)	10.28	7.4–12.7	P=0.2
Hb at 48 h (g/dl)	10.3	8.2–12.9	P=0.2
BU transfused	1.8	0–4	P=0.2

BU = blood units

The mean number of blood units transfused were 2 (range 0–5) in group A and 1.8 (range 0–4) in group B; no statistical difference was found (P = 0.2) (Table 3).

Complications

One of the complications in group A was a patient with a flexion contraction at 3 weeks, which was resolved after a second operation. In group B one patient needed reintervention 2 h after surgery because of a blood loss of 1,200 cc, treated by coagulating two medium calibre vessels that were still bleeding. Another patient in group B had a deep wound infection 10 days after the initial surgery, treated by surgical lavage and antibiotic therapy.

Discussion

In a study by Barwell [2], there was no significant difference in operating time nor decrease in haemoglobin at 48 h postoperatively with the early release of ischaemia; but they did demonstrate less postoperative pain, better range of motion and fewer wound complications. Abdel-Salam [1] did not find any differences in operating time or blood loss when comparing the use or not of a tourniquet; but they did observe less postoperative pain in patients without the use of a tourniquet.

Burkart [3], Widman [20] and Hersekli [8] found that releasing ischaemia prior to wound closure did not have any benefits when comparing blood loss and the need of transfusion. Schuh [18] found the same results, but observed an increase in deep vein thrombosis in patients that did not have the tourniquet released for haemostasis.

In a publication by Gutiérrez-Alamo [6], releasing ischaemia early allowed them to check the integrity of blood vessels and to control any major haemorrhage.

Henderson [7] found that releasing the tourniquet after wound closure decreases the operative blood loss, having this blood in the postoperative drainage and increasing the possibility of reinfusion. As a result, the use of bank blood is reduced, decreasing the risk of infection and the length of stay in the hospital [14, 16].

In our study no statistical differences were found in the postoperative haemoglobin, the total blood loss and the transfusions that were needed between the group with early release of the tourniquet and the group with release after suturing and bandaging. One of the complications in group B was major blood loss right after surgery that needed reintervention. We assume that this could have been avoided if the tourniquet had been released beforehand.

We conclude that releasing ischaemia prior to wound closure has no statistical effect compared to release after suturing and bandaging, but as with other authors, we found clinical advantages in the early release group, suggesting the need of further study of this situation.